UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis
By S. Koizumi, Yukari Shigemoto-Mogami, Kaoru Nasu-Tada, Y. Shinozaki, K. Ohsawa, M. Tsuda, B. Joshi, Kenneth A. Jacobson, S. Kohsaka, Kazuhide Inoue. Nature, 2007
802 citations recorded by the source corpus.
Subfields: Immunology, Neurology, Physiology
View Paper: https://www.semanticscholar.org/paper/b2818c55b86a947b885169d93389d56ecacf44e8
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In Immunology
- R. Ransohoff
- Kaoru Saijo
- V. Perry
- K. Ravichandran
- Christopher K. Glass
- U. Lorenz
- I. Tabas
- Berislav Zlokovic
In Neurology
- R. Ransohoff
- Christopher K. Glass
- Kaoru Saijo
- V. Perry
- Robin J. M. Franklin
- G. Burnstock
- C. Iadecola
- Guo-Yuan Yang
In Physiology
- R. Ransohoff
- V. Perry
- Christopher K. Glass
- G. Burnstock
- W. Junger
- Guo-Yuan Yang
- Yongting Wang
- Jixian Wang
Citations in the corpus
- Purinergic signalling and disorders of the central nervous system (2008, background): “In addition, P2Y 6 receptors are upregulated to limit secondary damage by mediating the phagocytosis of debri”
- Debris clearance by microglia: an essential link between degeneration and regeneration (2008, background): “In addition, a number of microglia-specific phagocytic receptors have been observed recently, including microglial metabotropic P2Y6 receptor that recognizes the nucleotide UDP released from injured neurons and stimulates microglial phagocytosis (Koizumi et al., 2007).”
- Microglial cell origin and phenotypes in health and disease (2011, background): “In addition, UDP released from dying neurons triggers microglial cell P2Y6 receptors and induces phagocytosis of the neurons by microgli”
- Engulfment of apoptotic cells: signals for a good meal (2007, background): “In a recent report, nucleotides (such as ATP and UTP) released by damaged neurons in mice induced the movement of microglial cells (macrophage-like phagocytes in the brain) to the damaged site”
- Live imaging of neuronal degradation by microglia reveals a role for v0-ATPase a1 in phagosomal fusion in vivo. (2008, neutral): “recent work has identified the P2Y12 purinergic receptor as the trigger of microglial chemotaxis and phagocytosis in response to neuronal injury in the brain (Koizumi et al., 2007; Tsuda et al., 2003).”
- Microglial physiology: unique stimuli, specialized responses. (2009, background): “Neuronal cell death or injury confronts microglia with a requirement to function as phagocytes, and another purinergic receptor, P2Y6, acting in a longer time frame than P2Y12 (which transduces signals within seconds), appears to play a significant role in microglial phagocytosis (80).”