Alzheimer's disease: the cholesterol connection

By L. Puglielli, Rudolph E. Tanzi, D. Kovacs. Nature Neuroscience, 2003

863 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b276bce7caefb0b12b8f06a504a09ad9a894c67c

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Citations in the corpus

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy (2009, background): “At the cellular level, the effect of cholesterol on the amyloidogenic processing of APP to Aβ remains controversia”
Upregulated function of mitochondria-associated ER membranes in Alzheimer disease (2012, positive): “…AD is intriguing: the enzyme is absolutely required for the generation of A b , by modulating the equilibrium between free and esteriﬁed cholesterol (Puglielli et al , 2001, 2003, 2004; Pottekat and Menon, 2004), presumably as a result of its affects on APP processing (Huttunen et al , 2009a, b;…”
Cholesterol metabolism and homeostasis in the brain (2015, positive): “ABCA and ABCG are the major classes in the brain, they are critical for lipid homeostasis (Dean et al., 2001; Schmitz et al., 2000; Puglielli et al., 2003).”
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses (2008, background): “Aβ production and clearance have been shown to be regulated by cholesterol, and drugs that inhibit cholesterol synthesis lower Aβ in cellular and animal model”
Pathways towards and away from Alzheimer's disease (2004, background): “Individuals that consume diets high in cholesterol and those with increased cholesterol levels may be at increased risk of AD, whereas those who take cholesterol-lowering drugs (statins) may be at reduced ris”
Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? (2004, background): “There is also increasing interest in the link between hypercholesterolemia, oxidative stress and AD (Refolo et al., 2001; Leonarduzzi et al., 2002; Puglielli et al., 2003; Wolfrum et al., 2003; Ong & Halliwell, 2004).”
Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs (2004, result): “This hypothesis is supported by epidemiologic studies showing a link between elevated cholesterol and Alzheimer diseas”