Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability.
By Bernhard Mlecnik, Gabriela Bindea, H. Angell, P. Maby, Mihaela Angelova, D. Tougeron, S. Church, Lucie Lafontaine, Maria Fischer, T. Fredriksen and 22 more. Immunity, 2016
930 citations recorded by the source corpus.
Subfields: Oncology, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/92db52e3cdb679e285cb821387abfb55744f388c
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In Oncology
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Citations in the corpus
- Spatially organized multicellular immune hubs in human colorectal cancer (2021, background): “, 2019) are often found below the invasive margin of tumors (Mlecnik et al., 2016), contain germinal center B cells, and have been associated with high T cell activity, favorable prognosis, and effective response to immunotherapy (Cabrita et al.”
- Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: a comprehensive review of registration trials and future considerations (2018, background): “as a strong prognostic indicator in CRC with potential to guide immunotherapy strategies [66].”
- Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy (2017, background): “In MSS CRC patients, a higher expression of genes involved with epithelial to mesenchymal transition (EMT) has been reported, an event that is associated with the invasiveness and spreading of tumor cells [60].”
- Inflammation and Cancer: Triggers, Mechanisms and Consequences (2019, background): “Increased accumulation of cytotoxic T and NK cells at the invasive margin of the primary tumor, along with decreased presence of myeloid cells as a part of the “cancer immunoscore” indeed correlates with better prognosis (Bindea et al., 2013; Mlecnik et al., 2016).”
- Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures (2016, neutral): “6 × 10, n = 271) [39] (Fig.”
- Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front (2019, background): “Recent studies of immunophenotypes in CRC have shown that the immune cell density is higher at the tumor invasive margin than in the tumor center (Bindea et al., 2013; Mlecnik et al., 2016).”