Genetic Variant BDNF (Val66Met) Polymorphism Alters Anxiety-Related Behavior

By Zhe-Yu Chen, D. Jing, K. Bath, A. Ieraci, Tanvir R. Khan, C. Siao, D. G. Herrera, M. Toth, Chingwen Yang, Bruce S. McEwen and 2 more. Science, 2006

1,374 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/b1eccd8e9afcd82d825823fc31abc8c0929c2cba

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. E. Nestler
2. L. Monteggia
3. V. Krishnan
4. S. Russo
5. Keri Martinowich
6. Anita E. Autry
7. B. Lu
8. W. Renthal

In Cognitive Neuroscience

1. V. Krishnan
2. S. Russo
3. Alisa Powers
4. O. Berton
5. E. Nestler
6. B. Fritsch
7. C. Kwon
8. B. Casey

In Developmental Neuroscience

1. E. Nestler
2. Keri Martinowich
3. L. Monteggia
4. Anita E. Autry
5. B. Lu
6. V. Krishnan
7. M. Götz
8. B. Casey

Citations in the corpus

• New insights in the biology of BDNF synthesis and release: implications in CNS function (2009, neutral): “…changes in humans and in mouse models, including abnormal feeding behavior, alterations in episodic memory, and susceptibility to neuropsychiatric disorders of anxiety and depression (Lyons et al., 1999; Egan et al., 2003; Chen et al., 2006; Castren and Rantamaki, 2008; Russo et al., 2009).”
• The Adolescent Brain and the Emergence and Peak of Psychopathology (2015, methodology): “We based our human studies on a knock-in mouse model associated with anxiety (Chen et al., 2006).”
• Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. (2007, methodology): “Similarly, BDNF levels from human NAc were assayed from homogenized and lysed protein extracts using previously published protocols (Chen et al., 2006).”
• New insights into BDNF function in depression and anxiety (2007, background): “In a mouse knock-in model carrying the Val66Met polymorphism, activity-dependent secretion of BDNF is significantly reduced, whereas total levels of BDNF as well as its constitutive secretion are not change”
• TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment (2008, positive): “Interestingly, recent generation of mutant mice carrying the same polymorphism indicates a causative link between the genetic change and elevated anxiety-like behaviors that are not normalized by ADs (Chen et al., 2006).”
• BDNF — a key transducer of antidepressant effects (2015, background): “Mice homozygous for this BDNF SNP (BDNF met/met) recapitulate the memory phenotypes reported in humans with this SNP (Chen et al., 2006).”
• Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders (2012, background): “In rodent studies, the V66M mutation is correlated with impaired fear memory (Chen et al., 2006), similar to findings with another BDNF mouse model (Monteggia et al.”
• Direct current stimulation promotes BDNF-dependent synaptic plasticity: Potential implications for motor learning (2010, positive): “Consistent with the human experiment, BDNFMet/Met knockin mice (Chen et al., 2006) exhibited significantly less skill acquisition on an accelerating rotarod task over 5 days of training compared to wild-type littermates (Figures 3D–3F, p = 0.047).”