Dopamine Receptor Signaling

By K. Neve, Jeremy K. Seamans, H. Trantham-Davidson. Journal of Receptor and Signal Transduction Research, 2004

858 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b1c677b390460bedeaf4623193ab66b52033a795

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Citations in the corpus

The Neuroscience of Drug Reward and Addiction. (2019, neutral): “…NAc binds to both D1R-expressing MSNs, where DA is stimulatory (increases cAMP and intracellular Ca signaling), and D2R-expressing MSNs where DA is inhibitory (decreases cAMP and intracellular Ca signaling) (213, 245, 297, 298), sparking the motivation to initiate reward-directed behaviors (346).”
Dopamine in motivational control: rewarding, aversive, and alerting (2010, background): “…likely to differ widely between these regions because of variations in the density of DA innervation, DA transporters, metabolic enzymes, autoreceptors, receptors, and receptor coupling to intracellular signaling pathways (Neve et al., 2004; Bentivoglio and Morelli, 2005; Frank and Fossella, 2010).”
New trends in the electrochemical sensing of dopamine (2012, background): “In the neurotransmission process, dopamine acts as an extrasynaptic messenger molecule via volume transmission across the synaptic cleft to bind to extrasynaptic receptors (G protein-coupled receptors) and transporters [12–16] (Fig.”
Dopaminergic Modulation of Cortical Inputs during Maturation of Adult-born Dentate Granule Cells (2011, background): “There is also evidence that both families may couple to phospholipase C (PLC)-mediated mobilization of intracellular Ca 2 (Neve et al., 2004).”
Modulation of striatal projection systems by dopamine (2011, neutral): “These receptors are grouped into two classes based on the G-protein to which they couple: D1, D5 (D1-like) receptors stimulate Gs and Golf proteins, whereas D2, D3, and D4 (D2-like) receptors stimulate Go and Gi proteins (Neve et al., 2004).”
Dopaminergic modulation of synaptic transmission in cortex and striatum (2012, background): “These signaling cascades are described in detail elsewhere (see Beaulieu and Gainetdinov, 2011; Fisone, 2010; Neve et al., 2004 and references within); only a brief overview is presented here.”
Title: Does the difference between physically active and couch potato lie in the dopamine system? (2010, neutral): “Possible signaling pathways in the dopaminergic neurons are extensively reviewed by Neve and colleagues (2004) [107], and these downstream signaling pathways may be important in future investigations of the role of the dopamine system and regulation of voluntary physical activity.”