Title: Does the difference between physically active and couch potato lie in the dopamine system?
By A. Knab, J. Lightfoot. International Journal on Biological Sciences, 2010
811 citations recorded by the source corpus.
Obesity and other inactivity related diseases are increasing at an alarming rate especially in Western societies. Because of this, it is important to understand the regulating mechanisms involved in physical activity behavior. Much research has been done in regard to the psychological determinants of physical activity behavior; however, little is known about the underlying genetic and biological factors that may contribute to regulation of this complex trait. It is true that a significant portion of any trait is regulated by genetic and biological factors. In the case of voluntary physical activity behavior, these regulating mechanisms appear to be concentrated in the central nervous system. In particular, the dopamine system has been shown to regulate motor movement, as well as motivation and reward behavior. The pattern of regulation of voluntary physical activity by the dopamine system is yet to be fully elucidated. This review will summarize what is known about the dopamine system and regulation of physical activity, and will present a hypothesis of how this signaling pathway is mechanistically involved in regulating voluntary physical activity behavior. Future research in this area will aid in developing personalized strategies to prevent inactivity related diseases.
Subfields: Cellular and Molecular Neuroscience, Clinical Psychology, Physiology
View Paper: https://www.semanticscholar.org/paper/858b3bb1c6c0b8fec4844b4e8eb282e643c39f79
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In Cellular and Molecular Neuroscience
In Clinical Psychology
In Physiology
Citations in the corpus
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- Microbial β-Glucosidase: Sources, Production and Applications (2017, background): “β-(1-4) O-glycosidic bonds ranging from 800-10000 units forming a chain with average molecular weight of 100000 Da [4,7,16,17,18].”
- Exercise metabolism and the molecular regulation of skeletal muscle adaptation. (2013, neutral): “…shows that peripheral differences in metabolism and physiological function are minimal between groups, and the majority of this biological variation is explained by central factors, most likely at the level of the dopaminergic system (reviewed in Knab and Lightfoot, 2010; Garland et al., 2011).”
- Personality in sport: a comprehensive review (2013, neutral): “One possible avenue for research is to explore the dopamine receptor genes associated with both personality (Munafò et al., 2008; Noble et al., 1998) and participation in sport and physical activity (Knab & Lightfoot, 2010; Lightfoot, 2011).”