Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer

By S. Nagaraj, K. Gupta, V. Pisarev, L. Kinarsky, Simon Sherman, Loveleen C. Kang, Donna L. Herber, J. Schneck, D. Gabrilovich. Nature Medicine, 2007

1,186 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/b18a720a025ebcc5c27e0a512e6691645775855b

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In Immunology

Citations in the corpus

The nature of myeloid-derived suppressor cells in the tumor microenvironment (2016, background): “These mechanisms include production of NO and ROS (including PNT) [12,44,81], and elimination of key nutrition factors needed for T cell proliferation by depleting L-arginine (via Arg1) [45], sequestering L-cysteine [46], or reducing local tryptophan levels due to the activity of indole amine 2,3 di”
Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer (2009, background): “MDSC suppression of CD8 T cells has been shown to be MHC restricted and Ag specific (57).”
Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor. (2010, background): “, Nos1 and Nos3), or components of the phagocytic oxidase (Cyba and Cybb), were described to contribute to MDSC’s ability to restrain T lymphocyte activation and proliferation (Bronte et al., 2005; Nagaraj et al., 2007).”
HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment (2010, methodology): “The main paradox is that, despite the presence of a large number of MDSCs in spleens and lymph nodes of tumor-bearing mice and in the peripheral blood of cancer patients with advanced disease, T cells mostly retain the ability to respond to different tumor-nonspecific stimuli including viruses, lect”
NRF2, a Transcription Factor for Stress Response and Beyond (2020, background): “However, Nfe2l2-null MDSCs have higher levels of intracellular ROS that suppress CTLs proliferation and induces T-cell anergy, a state of loss of CTLs antigen recognition, resulting in the increased tumor metastasis in a xenograft model of lung cancer [139,140].”
Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression (2018, positive): “In the presence of low L-arginine levels, which can occur due to metabolite depletion by MDSCs, iNOS was demonstrated to stimulate the production of peroxynitrites (ONOO2), highly reactive radicals that can cause T cell apoptosis, as well as nitration of the T cell receptors (TCRs), thereby blocking”