Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues.

By T. Furuyama, T. Nakazawa, Itsuko Nakano, N. Mori. Biochemical Journal, 2000

724 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b16060420efa6ebdcec2699a93287efb45803d36

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Citations in the corpus

FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons (2003, background): “…A search of the 5 end of the bim gene identified four potential FOXO binding sites that closely match a consensus GTAAACAA described previously (Furuyama et al., 2000), two of which—one at position 204 relative to the transcription start site (bim1) and one at the boundary between exon 1 and…”
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. (2007, neutral): “In cell culture-based systems, FoxO1, FoxO3, and FoxO4 behave similarly in biochemical studies, appear to regulate common target genes, and bind to the same target DNA sequence (Biggs et al., 2001; Brunet et al., 1999; Furuyama et al., 2000).”
FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK (2004, result): “…pSVE-RASV12 (Wolthuis et al, 1997), pMT2-HA-RalGEF2 (de Bruyn et al, 2000), pMT2-HA-JNK1, pMT2-HA-JNK3 (de Groot et al, 1997), 6xDBE-luciferase (Furuyama et al, 2000) and pSODLUC-3340 (Kim et al, 1999). pRL-Tk (Tk Renilla luciferase) was purchased from Promega. pMT2-HA-FOXO4-T451E and…”
Stressing the role of FoxO proteins in lifespan and disease (2007, background): “The DNA-binding domain of FoxO, in particular helix three, binds to the consensus motif 5′-TTGTTTAC-3′ (Ref”
Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. (2003, background): “Previously we found that treating wild- type animals with daf-2 RNAi doubled lifespan, and that target of DAF-16 (Furuyama et al., 2000; Honda and Honda, 1999).”
FoxO transcription factors in the maintenance of cellular homeostasis during aging. (2008, background): “In mammals, FoxO isoforms display differential but overlapping expression throughout the organism In mammals, the FoxO family have a complementary but overlapping expression pattern both during development and in a variety of adult tissues [5,51–53].”
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans (2003, background): “We found that the sequence T(G/A)TTTAC, which has been shown to be bound by DAF-16 in vitro”
FoxM1 is required for execution of the mitotic programme and chromosome stability (2005, background): “Indeed, whereas expression of full-length haemagglutinin (HA)-tagged FoxM1 caused a clear induction of a luciferase reporter gene containing six Forkhead binding sites (6xDB) within its promote”