Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production

By W. Naugler, T. Sakurai, Sunhwa Kim, S. Maeda, Kyounghyun Kim, A. Elsharkawy, M. Karin. Science, 2007

1,856 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/b155f9b12573c772f09adb35b382b0dfac1ecde1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

In Molecular Biology

In Oncology

Citations in the corpus

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. (2011, background): “Interestingly, IL-6 was responsible for the higher prevalence of liver cancer in male littermates in this model (105).”
Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression (2010, background): “kept on LFD, an observation consistent with previous findings (Naugler et al., 2007), hardly exhibited any augmentation of tumor multiplicity, size, and incidence when placed on HFD (Figures 5A and 5B).”
Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4 (2012, methodology): “However, the increased liver injury is unlikely to cause decreased hepatocarcinogenesis in Tlr4mut mice as liver injury after DEN is thought to promote hepatocarcinogenesis by inducing regenerative responses (Maeda et al., 2005; Naugler et al., 2007).”
Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver. (2012, positive): “This bias is believed to be partially attributable to the greater susceptibility of males to injury-induced hepatic inflammation and hepatocyte proliferation mediated by IL-6, whose production is suppressed by estrogens in females (39).”
Sexual Dimorphism in Innate Immunity (2019, neutral): “In a recent study from the Human Functional Genomics Project, a major project that assessed the variability of human cytokine responses to a large panel of microbial and metabolic stimuli in a group of 500 healthy volunteers; female sex was associated with higher circulating levels of IL-1Ra, lower ”
Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution. (2016, positive): “In particular for the DEN-induced liver model, used in this study, Naugler and colleagues showed that IL-6 KO mice were resistant to DEN-induced tumor formation (Naugler et al., 2007).”
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. (2009, background): “In females, estrogen steroid hormones inhibit IL-6 production and so protect female mice from cancer [35,36].”