Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen

By A. Brass, D. Dykxhoorn, Yair Benita, Nan Yan, A. Engelman, Ramnik J. Xavier, J. Lieberman, Stephen J. Elledge. Science, 2008

1,405 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Virology

View Paper: https://www.semanticscholar.org/paper/b124f2c1f878a252dd3372a150e24c81120711de

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Citations in the corpus

Human Host Factors Required for Influenza Virus Replication (2010, positive): “Genome-wide RNAi screens have enabled the identification of host factors required by a number of RNA viruses 5–7 8 9, 10 11, including an insect cell-based RNAi screen which implicated 110 Drosophila genes in influenza virus replication 12.”
A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection. (2009, background): “Previous studies on viral and host factors have focused on specific interactions but have not produced global models of the viral-host relationship, with few exceptions (Brass et al., 2008; Bushman et al., 2009; König et al., 2008; Krishnan et al., 2008; Li et al., 2009).”
Global analysis of host-pathogen interactions that regulate early stage HIV-1 replication (2008, methodology): “Our studies, combined with those of Brass et al. (2008), indicate the involvement of NUP153, RANBP2, and TNPO3 as factors involved in HIV-1 PIC import (Table 1).”
Autophagy, Immunity, and Microbial Adaptations (2009, methodology): “N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript Table 2 Microbial Adaptations to Evade or Use Autophagy to Promote Survival or Replication Microbe Adaptation Effects on hostpathogen interactions Microbial virulence factor/mechanism References VIRUSES RNA viruses P”
Prioritizing candidate disease genes by network-based boosting of genome-wide association data. (2011, background): “down (Brass et al. 2008), were predictable by guilt-by-association in HumanNet.”
HIV-1 accessory proteins--ensuring viral survival in a hostile environment. (2008, background): “Interestingly, DCAF1 was also identified as an HIV-1-dependency factor (i.e., a protein whose expression promotes replication) in a large-scale siRNA screen using a viral strain that was deficient for Vpr (Brass et al., 2008).”
Semi-supervised multi-task learning for predicting interactions between HIV-1 and human proteins (2010, methodology): “We combine these three human gene lists with the one in Brass et al. (2008) to form a combined list called as ‘CombineFourSiRNA’ in Table 3.”
Genome-scale RNAi screen for host factors required for HIV replication. (2008, methodology): “(B) Effects of siRNA hits identified in this work and in Brass et al. (2008) on HIV replication.”
displayHTS: a R package for displaying data and results from high-throughput screening experiments (2013, neutral): “High-throughput screening (HTS) technologies play a critical role in modern biological research and drug discovery (Brass et al ., 2008).”
IFITM Proteins Mediate the Innate Immune Response to Influenza A H1N1 Virus, West Nile Virus and Dengue Virus (2009, methodology): “…S2), including a summary comparison of enriched GO categories for three whole-genome screens for host-factor modifiers of viral infection (HIV, [Brass et al., 2008], influenza A virus [this study], and WNV [Krishnan et al., 2008]), wherein each screen’s respective candidate gene list was…”