Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats.

By H. Scharfman, J. Goodman, Ad Macleod, Sudarshan Phani, Cara Antonelli, S. Croll. Experimental Neurology, 2005

733 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/b10259cd164528a70f1660e6201ac84e7c5fef6c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Fred H. Gage
2. Wei Deng
3. H. van Praag
4. R. Duman
5. H. Schmidt
6. Gregory D. Clemenson
7. B. Lu
8. M. Marchetto

In Developmental Neuroscience

1. Fred H. Gage
2. Wei Deng
3. H. van Praag
4. R. Duman
5. H. Schmidt
6. Gregory D. Clemenson
7. Hongjun Song
8. B. Lu

Citations in the corpus

• TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment (2008, background): “These observations, coupled with evidence that exogenous BDNF promotes proliferation of hippocampal NPCs (Scharfman et al., 2005), suggest an important role for BDNF in mediating the biological response to chronic AD treatments (Wang et al.”
• Brain-derived Neurotrophic Factor Promotes Differentiation and Maturation of Adult-born Neurons Through GABAergic Transmission (2012, background): “While exogenous BDNF injected into the murine hippocampus was reported to increase proliferation (Scharfman et al., 2005), conditional knock-out mice lacking BDNF in mature neurons displayed increased proliferation as well (Chan et al., 2008).”
• Aberrant seizure‐induced neurogenesis in experimental temporal lobe epilepsy (2006, background): “Seizures result in upregulation of brain-derived neurotrophic factor in the dentate gyrus,(46,47) and intrahippocamal infusion of brain-derived neurotrophic factor induces hilar-ectopic DGC formation in intact adult rats.(48) Thus, seizure-induced upregulation of migration guidance cues and trophic ”
• The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “In contrast, chronic administration of BDNF directly into the hippocampus increases neurogenesis (Scharfman et al., 2005).”
• Environmental enrichment and neurogenesis: from mice to humans (2015, background): “Direct infusion of BDNF into the hippocampus resulted in an increase in neurogenesis [33].”
• Exercise and the brain: something to chew on (2009, background): “Furthermore, intracerebral infusion of BDNF increased cell genesis in the dentate gyrus [99], but not in the subventricular zone [100], consistent with data showing that the neurogenic effect of exercise is limited to the hippocampus [101].”
• BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “However, BDNF, which is known to be important for various aspects of hippocampal plasticity including neurogenesis and spatial memory (90, 116, 202), is not the only mediator of the effects of T cells on the hippocampus.”
• BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity (2017, background): “In vivo studies showed that BDNF is involved in regulation of neurogenesis in the adult hippocampus (Katoh-Semba et al. 2002; Lee et al. 2002; Scharfman et al. 2005).”
• Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways (2006, background): “sis in the subgranular zone of the DG (Scharfman et al., 2005).”
• Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells (2014, background): “, 2011), as well as brain-derived growth factor (BDNF), a neurotrophic factor found to promote hippocampal neurogenesis throughout life (Scharfman et al., 2005; Erickson et al., 2010) (Figure 1A).”