Inflammasomes: mechanism of assembly, regulation and signalling

By Petr Brož, Vishva M. Dixit. Nature reviews. Immunology, 2016

3,082 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/b0fae6ab4f28b5c0aed900b1705f4015d9c125ad

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In Immunology

1. M. Lamkanfi
2. F. Shao
3. G. van Loo
4. A. Grebe
5. E. Latz
6. Florian Hoss
7. Jianjin Shi
8. T. Kanneganti

In Molecular Biology

1. M. Lamkanfi
2. F. Shao
3. Jingjin Ding
4. Kun Wang
5. G. van Loo
6. Wenqing Gao
7. A. Grebe
8. E. Latz

In Surgery

1. M. Lamkanfi

Citations in the corpus

• Mitochondrial DNA in inflammation and immunity (2020, neutral): “However, the role of NLRP3 as a direct sensor of DNA is contentious, as many disparate signals have been reported as the common signal for NLRP3 activation [144].”
• Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis. (2020, background): “Pyroptosis is a lytic cell death induced by pathogen infection or endogenous challenge (Broz and Dixit, 2016; Jorgensen and Miao, 2015; Rathinam et al., 2019).”
• Inflammasomes in neuroinflammatory and neurodegenerative diseases (2019, background): “…are cytosolic multiprotein complexes which upon assembly activate the pro-inflammatory caspase-1 (see Glossary) that is responsible for the maturation and secretion of the inflammatory cytokines IL-1b and IL-18, and additionally induce pyroptosis (Lamkanfi & Dixit, 2014; Broz & Dixit, 2016).”
• Reconfigurable asymmetric protein assemblies through implicit negative design (2021, neutral): “A different type of branched assemblies are “ starshaped ” oligomerswithcyclicsymmetries, akin to natural assemblies formed by immunoglobulin M (IgM) and the inflammasome ( 31 , 32 ).”
• Pattern Recognition Receptors and the Host Cell Death Molecular Machinery (2018, background): “There are five major types of the so-called canonical inflammasomes—NLR pyrin domain-containing 3 (NLRP3), NLRP1, neuronal apoptosis inhibitory protein (NAIP)/NLR CARD-containing 4 (NLRC4), absent in melanoma 2 (AIM2), and PYRIN inflammasomes (139).”