Inflammasomes in neuroinflammatory and neurodegenerative diseases

By Sofie Voet, Sahana Srinivasan, M. Lamkanfi, G. van Loo. EMBO Molecular Medicine, 2019

631 citations recorded by the source corpus.

Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid‐β, α‐synuclein, and prions, that can activate inflammasomes. Inflammasomes function as intracellular sensors of both microbial pathogens and foreign as well as host‐derived danger signals. Upon activation, they induce an innate immune response by secreting the inflammatory cytokines interleukin (IL)‐1β and IL‐18, and additionally by inducing pyroptosis, a lytic cell death mode that releases additional inflammatory mediators. Microglia are the prominent innate immune cells in the brain for inflammasome activation. However, additional CNS‐resident cell types including astrocytes and neurons, as well as infiltrating myeloid cells from the periphery, express and activate inflammasomes. In this review, we will discuss current understanding of the role of inflammasomes in common degenerative diseases of the brain and highlight inflammasome‐targeted strategies that may potentially treat these diseases.

Subfields: Biological Psychiatry, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d3255a9bcc2b3b084951d735f239f57a389d2e7e

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Citations in the corpus

• Role of neuroinflammation in neurodegeneration development (2023, background): “Inflammasomes Inflammasomes are cytosolic multiprotein complexes consisting of the cytosolic sensor protein, the adapter apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and pro-caspase-1.(346) Upon activation, the PRR protein, i.”
• Anthocyanins: A Comprehensive Review of Their Chemical Properties and Health Effects on Cardiovascular and Neurodegenerative Diseases (2020, background): “The prominent innate immune cells in the brain for inflammasome activation are microglia; however, additional resident cell types as astrocytes and neurons can also express and activate inflammasomes [250].”