Lipid metabolism in cancer.
By Daniel K. Nomura, B. Cravatt. Biochimica et Biophysica Acta, 2013
1,195 citations recorded by the source corpus.
Subfields: Biochemistry, Cancer Research, Immunology
View Paper: https://www.semanticscholar.org/paper/b0dd29f938dc485974396e7f2e30dc87c173865d
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In Biochemistry
In Cancer Research
In Immunology
Citations in the corpus
- The multifaceted roles of fatty acid synthesis in cancer (2016, background): “signalling via LPA receptors (LPARs), and production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3; also known as PtdIns(3,4,5)P3) activates AKT.”
- Cellular Fatty Acid Metabolism and Cancer (2013, background): “Lipidmetabolism is also altered in rapidly proliferating cells (for general reviews, see Swinnen et al., 2006; DeBerardinis and Thompson, 2012; Santos and Schulze, 2012).”
- Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration (2015, positive): “A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript Cells other than adipocytes can form LDs as a response to cellular inflammation and stress (Santos and Schulze, 2012).”
- Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development (2013, background): “…tissues show aberrant activation of de novo lipogenesis and that inhibition of different enzymes within the FA biosynthesis pathway can block cancer cell growth (reviewed by Abramson, 2011; Igal, 2010; Menendez and Lupu, 2007; Santos and Schulze, 2012; Swinnen et al., 2006; Zaidi et al., 2012).”
- Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness (2014, background): “Among dysregulated metabolic pathways, increased de novo synthesis of lipids has become a common characteristic of human cancers (Santos and Schulze, 2012).”