The multifaceted roles of fatty acid synthesis in cancer

By F. Röhrig, A. Schulze. Nature Reviews. Cancer, 2016

1,422 citations recorded by the source corpus.

Subfields: Biochemistry, Cancer Research

View Paper: https://www.semanticscholar.org/paper/3ff4edc801490b79fa04222ce229a57d84c12166

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. Nikos Koundouros
2. Guido Kroemer
3. G. Poulogiannis

In Cancer Research

1. L. Galluzzi
2. Guido Kroemer
3. Nikos Koundouros
4. J. B. Pedro
5. P. Porporato
6. G. Poulogiannis
7. N. Filigheddu

Citations in the corpus

• Mitochondrial metabolism and cancer (2017, background): “One key TCA intermediate in this respect is citrate, because it resides at a crucial intersection between catabolic and anabolic metabolism, and hence operates as a major node of flexibility [82].”
• Reprogramming of fatty acid metabolism in cancer (2019, background): “1).(3) In this review, we will explore how cancer cells sustain their FA metabolism in the context of a metabolically dynamic tumour microenvironment, and oncogenic signalling to support tumorigenesis and cancer progression.”
• Mutant p53 as a guardian of the cancer cell (2018, neutral): “by providing membrane lipids and supporting signaling pathways that promote proliferation and survival, EMT, cancer stem cells fate determination, and metastatic dissemination [40, 41].”
• Revisiting the hallmarks of cancer. (2017, neutral): “1034 Am J Cancer Res 2017;7(5):1016-1036 [155] Röhrig F and Schulze A.”
• Lipid metabolism reprogramming and its potential targets in cancer (2018, background): “Lipogenesis is strongly up-regulated in human cancers to satisfy the demands of increased membrane biogenesis [7, 8, 21, 23].”
• The interaction between ferroptosis and lipid metabolism in cancer (2020, background): “It is well known that lipid metabolism plays an extremely important role in various tumor properties, including tumorigenesis, invasion, and metastasis.(5) For example, high saturation levels of membrane lipids protect cancer cells from damage induced by reactive oxygen species (ROS), since saturate”