Regulated necrosis: the expanding network of non-apoptotic cell death pathways

By T. Vanden Berghe, A. Linkermann, S. Jouan-Lanhouet, H. Walczak, Peter Vandenabeele. Nature reviews. Molecular cell biology, 2014

1,644 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b05812e8918ccaf151ee318966139b261f89e543

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Citations in the corpus

Human Monocytes Engage an Alternative Inflammasome Pathway. (2016, neutral): “Please see also Figures S1 and S2. reminiscent of tumor necrosis factor receptor (TNFR) signaling, leading to complex IIb (ripoptosome) formation (Vanden Berghe et al., 2014).”
Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions (2022, background): “Instead, TNFR2 promotes cell growth and regeneration.(204,230,231) Given the important regulatory role of TNF signals in inflammation and other neurological processes, TNFs are likely involved in the pathophysiology of ischemic stroke.”
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018, background): “perturbations of the intracellular microenvironment such as severe oxidative stress and cytosolic Ca overload, which generally manifests with a necrotic morphotype [373, 374].”
Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF (2015, background): “Beside induction of classical apoptosis via complex II, TNFR1 is also capable of initiating cell death by a form of controlled necrosis called necroptosis [134].”
Neuronal Cell Death. (2018, neutral): “Phosphorylation of MLKL and formation of the necrosome are currently thought to occur primarily during necroptosis and are thus considered cellular markers of necroptosis (684).”
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 (2014, background): “The identification of a genetically encoded machinery that promotes RCD with necrotic features generated an intense wave of investigation that has not yet come to an end.(33,74,120,121) From a biochemical standpoint, apoptosis is defined as a caspase-dependent variant of RCD.”
The Development of the Concept of Ferroptosis (2018, neutral): “normal physiological functions, such as the modulation of inflammation and the maintenance of adult T-cell homeostasis [15,21,22], and may”
Identification of ACSL4 as a biomarker and contributor of ferroptosis. (2016, background): “Thus, induction of non-apoptotic forms of regulated cell death has become an emerging anticancer strategy for therapeutics [2].”