Uptake and Cytotoxicity of Chitosan Molecules and Nanoparticles: Effects of Molecular Weight and Degree of Deacetylation

By Min Huang, E. Khor, L. Lim. Pharmaceutical Research, 2004

820 citations recorded by the source corpus.

Subfields: Biomaterials, Organic Chemistry, Pharmaceutical Science

View Paper: https://www.semanticscholar.org/paper/b0495d8216589757b219236c89d045b5d102893f

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In Biomaterials

In Organic Chemistry

In Pharmaceutical Science

Citations in the corpus

Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 2) (2013, background): “[66] proved that the uptake of chitosan nanoparticles by A549 cells was initiated by electrostatic interactions between the nanoparticles and the cell membrane and Amidi et al.”
The effect of surface charge on the uptake and biological function of mesoporous silica nanoparticles in 3T3-L1 cells and human mesenchymal stem cells. (2007, background): “[17] showed that the degree of deacetylation had a greater influence than molecular weight on the uptake and cytotoxicity of chitosan nanoparticles in A549 cells.”
Chitin and Chitosan Preparation from Marine Sources. Structure, Properties and Applications (2015, background): “However, other authors found that decrease of MW of chitosan from 213 to 10 kDa does not affect its in vitro cytotoxicity on human lung carcinoma cell line A549 [221].”
Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy (2005, background): “Smaller particles occupy less volume, resulting in a larger number of particles with a greater surface area per unit mass and increased potential for biological interaction [42-46].”
Drug delivery and nanoparticles: Applications and hazards (2008, background): “The insert shows the application of the system with Rhodamine B encapsulated beads that is released after heating up to 45 o C.”
In vitro toxicity of silica nanoparticles in human lung cancer cells. (2006, methodology): “This cell line has been widely used in in vitro cytotoxicity studies (Huang et al., 2004; Bakand et al., 2006).”
Chitosan—A versatile semi-synthetic polymer in biomedical applications (2011, background): “However, several studies reported that the degradation rate is affected by the length of the chains (Mw) as well [28,39,40].”