In vitro toxicity of silica nanoparticles in human lung cancer cells.

By Weisheng Lin, Yue-Wern Huang, Xiao-Dong Zhou, Yinfa Ma. Toxicology and Applied Pharmacology, 2006

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Drug delivery and nanoparticles: Applications and hazards (2008, methodology): “Both 15 nm and 46 nm silica nanoparticles showed similar dose dependent cytotoxicity in vitro (Lin et al 2006).”
Nanoparticles as drug delivery systems (2012, background): “All of these events are responsible for lipid peroxidation and cell membrane damage [82].”
The nanosilica hazard: another variable entity (2010, background): “[102] investigated the cytotoxicity of amorphous (colloidal) SNPs (15 and 46 nm) in cultured”
NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. (2009, background): “Since the silica nanoparticles can result in increased ROS levels [83] and given that the hydroxyl radical is a highly reactive molecule the generation of OH close to the DNA could readily lead to the induction of DNA strand breaks and oxidised bases [22] which could have important implications in t”
Nanomaterial cytotoxicity is composition, size, and cell type dependent (2010, background): “In vitro studies have generally supported the pathophysiological responses found in animal models, including increased generation of ROS in cells exposed to various nanomaterials [9-12].”