The effect of surface charge on the uptake and biological function of mesoporous silica nanoparticles in 3T3-L1 cells and human mesenchymal stem cells.

By Tsai-Hua Chung, Si-Han Wu, M. Yao, Chen-Wen Lu, Yu-shen Lin, Y. Hung, C. Mou, Yao-chang Chen, Dong-Ming Huang. Biomaterials, 2007

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The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles (2011, neutral): “Surface charge has also been reported to play a major role to regulate the NPs uptake by macrophages [10,12].”
Sol-gel based materials for biomedical applications (2016, background): “For example, it was previously found that quaternary amine-functionalised MSNs tended to adhere to negatively charged components of cell membranes rather than penetrating the cells and entered the cytoplasm [396].”
The nanosilica hazard: another variable entity (2010, background): “0 nm) hMSCs 3T3-L1 • MTT assay • Flow cytometry for the uptake • Cellular differentiation and cytochemical assay • The modulation of surface charge and its threshold affects the uptake and is specific to cell type • Positive correlation of positive surface charge and the uptake by the cells • Uptake”
The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function. (2010, background): “have shown that MSN uptake by human mesenchymal stem cells depends on their threshold positive surface charge, but also imply that the effect of surface charge on uptake of MSNs is specific to cell type [8].”