Neural substrates of awakening probed with optogenetic control of hypocretin neurons

By Antoine Adamantidis, Feng Zhang, A. Aravanis, Karl Deisseroth, L. Lecea. Nature, 2007

1,271 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Endocrine and Autonomic Systems

View Paper: https://www.semanticscholar.org/paper/b01b9b401eadc12ee0b1108c45a3a85ee84914cc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Karl Deisseroth
2. Ofer Yizhar
3. Lief Ericsson Fenno
4. Logan Grosenick
5. James H. Marshel
6. Karel Svoboda
7. Edward M. Callaway
8. Liqun Luo

In Cognitive Neuroscience

1. Karl Deisseroth
2. Logan Grosenick
3. James H. Marshel
4. Lief Ericsson Fenno
5. Ofer Yizhar
6. Karel Svoboda
7. Edward M. Callaway
8. Viviana Gradinaru

In Endocrine and Autonomic Systems

1. Karl Deisseroth
2. Liqun Luo
3. Karel Svoboda
4. Edward M. Callaway
5. Feng Zhang
6. E. Arrigoni
7. J. Lipton
8. T. Scammell

Citations in the corpus

• Closed-loop and activity-guided optogenetic control. (2015, positive): “…parameters , varying light intensity and/or frequency to gain insight into the relationship between optogenetic stimulation and behavior (e.g., Adamantidis et al., 2007; Tsai et al., 2009; Cardin et al., 2009) and thoroughly characterizing the response of individual cells expressing…”
• Neural Circuitry of Wakefulness and Sleep (2017, positive): “ICV injection of orexin-A reduces REM sleep for many hours (Mieda et al., 2011), and photoactivation of the orexin neurons awakens mice from REM sleep (Adamantidis et al., 2007).”
• Neuromodulation of brain states. (2012, positive): “(Adamantidis et al., 2007 ), whereas loss of orexin, orexin receptors, or orexin neurons causes narcolepsy, a sleep disorder characterized by excessive sleepiness and sudden sleep attacks (Chemelli et al., 1999; Hara et al., 2001; Lin et al., 1999; Peyron et al., 2000).”
• Automated long-term recording and analysis of neural activity in behaving animals (2016, background): “Future experiments involving continuous long-term recordings in combination with optogenetic cell-type identification (Lima et al., 2009) and perturbations of neuromodulatory pathways (Adamantidis et al., 2007; Carter et al., 2010) will be able to inform this question.”
• Molecular and cellular approaches for diversifying and extending optogenetics. (2010, background): “Moroever, results thus far point to substantial versatility of the optogenetic approach across animal species (Adamantidis et al., 2007; Airan et al., 2009; Aravanis et al., 2007; Arenkiel et al., 2007; Bi et al., 2006; Boyden et al., 2005; Chow et al., 2010; Douglass et al., 2008; Gradinaru et…”
• Genetic dissection of neural circuits. (2008, positive): “For example, photostimulation of ChR2-positive hypocretin neurons accelerated the waking of sleeping mice (Adamantidis et al., 2007).”
• Synaptic plasticity, memory and the hippocampus: a neural network approach to causality (2008, background): “However, major strides have been made in solving this proble”
• CONTROL OF SLEEP AND WAKEFULNESS (2012, positive): “These studies include both older techniques of electrical stimulation or infusion of pharmacological agents as well as state-of-the-art optogenetic techniques where lightactivated ion channels are introduced into the desired neuronal population by genetic engineering techniques (6, 1473).”