Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome

By Toshiya Tanaka, Joji Yamamoto, S. Iwasaki, H. Asaba, H. Hamura, Y. Ikeda, Mitsuhiro Watanabe, K. Magoori, Ryoichi X. Ioka, K. Tachibana and 12 more. Proceedings of the National Academy of Sciences of the United States of America, 2003

872 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/afff50bf6734bd256712b7b3fd588c4ab944339f

How researchers see this paper

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In Molecular Biology

1. Johan Auwerx
2. M. Hock
3. A. Kralli
4. Mitchell A. Lazar
5. B. Spiegelman
6. L. Michalik
7. W. Wahli
8. Bart Staels

In Physiology

1. B. Spiegelman
2. Johan Auwerx
3. M. Hock
4. A. Kralli
5. Mitchell A. Lazar
6. L. Michalik
7. W. Wahli
8. S. O’Rahilly

Citations in the corpus

• Regulation of Muscle Fiber Type and Running Endurance by PPARδ (2004, background): “While induction of muscle oxidation enzymes by PPAR d has been seen both in vivo and in vitro (Muoio et al. 2002; Dressel et al. 2003; Luquet et al. 2003; Tanaka et al. 2003; Wang et al. 2003), its effects shown here on muscle fiber switching are unexpected.”
• International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors (2006, background): “Further studies confirmed the functions of PPAR / in regulating energy homeostasis and lipid metabolism (Muoio et al., 2002; Dressel et al., 2003; Luquet et al., 2003; Tanaka et al., 2003; Bedu et al., 2005).”
• Transcriptional control of mitochondrial biogenesis and function. (2009, background): “Treatment of mice with an agonist PPARδ ligand enhances muscle lipid uptake, FAO, and mitochondrial biogenesis; it also increases expression of UCPs, GLUT4, and PGC-1α (53).”
• Regulation of energy metabolism by long-chain fatty acids. (2014, background): “PDK4 mRNA was highly induced in liver in response to peroxisome proliferator administration in mice [93], rats [94,83] and pigs [83].”
• Therapeutic roles of peroxisome proliferator-activated receptor agonists. (2005, background): “Treatment of obese mice with a PPAR agonist reduces obesity and insulin resistance via an effect on fatty acid oxidation in skeletal muscle (85).”
• Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. (2008, background): “PPARd has been shown to transcriptionally regulate oxidative metabolism in muscle and improve insulin sensitivity (Lee et al., 2006b; Schuler Cell Metabolism 7, 485–495, June 2008 ª2008 Elsevier Inc. 485 et al., 2006; Tanaka et al., 2003; Wang et al., 2003).”