Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP

By V. Soumelis, Pedro A. Reche, H. Kanzler, W. Yuan, G. Edward, B. Homey, M. Gilliet, S. Ho, S. Antonenko, A. Lauerma and 10 more. Nature Immunology, 2002

2,211 citations recorded by the source corpus.

Subfields: Dermatology, Immunology and Allergy, Physiology

View Paper: https://www.semanticscholar.org/paper/afbacd89af422d7e018836c0f54bbfedbffed35e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Dermatology

1. J. Girard
2. Frank O. Nestle
3. M. Tsai
4. S. Galli

In Immunology and Allergy

1. M. Tsai
2. S. Galli
3. Rafi Ahmed
4. Bali Pulendran
5. S. Nakae

In Physiology

1. S. Galli
2. H. Hammad
3. B. Lambrecht
4. M. Tsai
5. D. Artis
6. S. Nakae

Citations in the corpus

• The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel ‘Alarmin’? (2008, background): “IL-33 could act alone or in concert with other mediators, such as thymic stromal lymphopoietin (TSLP), which is also expressed by inflamed skin and tonsillar crypt epithelium, and can be released by epithelial cells in response to trauma or infection [5,29,30].”
• Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity. (2005, background): “We recognize that other factors such as the recently identified thymic stromal lymphopoietin (TSLP) (37) may also be involved, since S-CM (and TSLP) downregulates monocytederived IL-10, which is not NF-κB mediated (38).”
• TSLP elicits IL-33–independent innate lymphoid cell responses to promote skin inflammation (2013, background): “The role of TSLP in promoting TH2 cytokine–associated inflammation in AD was first highlighted when lesional human AD skin was found to exhibit elevated expression of TSLP (31).”
• Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice (2005, background): “In vitro studies with a human TSLP ortholog have shown that TSLP can stimulate the differentiation and activation of CD11c + dendritic cells (DCs), inducing expression of the T H 2 cell–attracting chemokines CCL17 and CCL22 (ref”
• Skin immune sentinels in health and disease (2009, background): “Keratinocytes might also condition DCs to promote a dysregulated immune response, for example through the secretion of thymic stromal lymphopoietin in allergic inflammatio”
• Translating innate immunity into immunological memory: implications for vaccine development. (2006, neutral): “Furthermore, human epithelial cells trigger DC-mediated allergic inflammation by producing TSLP (Soumelis et al., 2002).”
• Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma (2017, background): “Human TSLPR uses three regions to grasp TSLP and buries B1,900Å2 of solvent exposed surface area: (1) the intersheet EF1 loop and N-terminal residues of the F strand of TSLPRD1 (residues 91–96), (2) the C-terminal residues of TSLPRD1 strand G and the interdomain linker connecting TSLPRD1 and TSLPRD2”