Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation

By Carl-Philipp Heisenberg, M. Tada, Gerd-Jörg Rauch, L. Saúde, M. Concha, R. Geisler, D. Stemple, James C. Smith, Stephen W. Wilson. Nature, 2000

1,066 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/af9312a75b6b9bc62546e7d8475faaf2736053cc

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In Molecular Biology

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Citations in the corpus

• LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: Arrows point the way (2004, background): “Similarly, in Xenopus, blocking Lrp6 function has little effect on gastrulation movements (Semenov et al., 2001), which are regulated by a Wnt11/Fz pathway analogous to Dfz1/PCP signaling (Heisenberg et al., 2000; Tada and Smith, 2000; Wallingford et al., 2000).”
• The receptor tyrosine kinase Ror2 is involved in non‐canonical Wnt5a/JNK signalling pathway (2003, background): “XWnt11, Xdsh, XJNK, tri/stbm) involved in non-canonical Wnt signalling in Xenopus or zebrafish (Heisenberg et al. 2000; Wallingford et al. 2000; Jessen et al. 2002; Pandur et al. 2002; Yamanaka et al. 2002).”
• Secreted antagonists of the Wnt signalling pathway (2003, background): “…Wnts (e.g. Wnt4, Wnt5A and Wnt11) activate other signalling pathways, such as the planar-cell-polarity (PCP)-like pathway that guides cell movements during gastrulation (Heisenberg et al., 2000) and the Wnt/Ca2+ pathway (discovered in zebrafish and Xenopus) (reviewed in Kuhl et al., 2000).”
• Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation. (2003, background): “Endogenous Rac protein was detected in equal amounts in dorsal and ventral marginal zone explants (DMZ vs. VMZ), but activated Rac was detected mainly in the DMZ (Fig.”
• Signalling in neural development: WNTS in the vertebrate nervous system: from patterning to neuronal connectivity (2005, neutral): “, the convergent extension movements during gastrulatio”
• Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway. (2000, background): “This conclusion is supported by genetic analysis in zebrafish showing that impaired M. Tada and J. C. Smith convergent extension movements in silberblick−/− embryos, which carry a null mutation in the Wnt11 gene, can be rescued by overexpression of Wnt11 RNA (Heisenberg et al., 2000).”
• Towards an integrated view of Wnt signaling in development (2009, background): “Conversely, Wnt proteins have been implicated in convergent extension and tissue polarity in vertebrates (Dabdoub et al., 2003; Heisenberg et al., 2000; Kilian et al., 2003; Qian et al., 2007).”
• The ankyrin repeat protein Diversin recruits Casein kinase Iε to the β-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling (2002, background): “In contrast, particular Wnt and Frizzled molecules, like Wnt11 and Fz7, specifically activate the Wnt/JNK, but not the canonical Wnt pathway (Djiane et al. 2000; Heisenberg et al. 2000).”