The receptor tyrosine kinase Ror2 is involved in non‐canonical Wnt5a/JNK signalling pathway

By I. Oishi, Hiroaki Suzuki, N. Onishi, R. Takada, Shuichi Kani, B. Ohkawara, Ikue Koshida, Kentarou Suzuki, G. Yamada, G. Schwabe and 4 more. Genes to Cells, 2003

789 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5d87087ec4e80615d55d2f035b8d1b7d8cfe12c1

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In Cell Biology

1. R. Nusse
2. Christof Niehrs

In Molecular Biology

1. R. Nusse
2. Christof Niehrs
3. S. Angers
4. R. Moon
5. Amanda J Mikels
6. Hans Clevers
7. G. Schulte
8. J. Petersen

Citations in the corpus

• Towards an integrated view of Wnt signaling in development (2009, background): “Single-pass transmembrane receptor tyrosine kinases (RTKs) of the Ryk and Ror families appear to function as genuine Wnt receptors, with Wnt interactions mediated by Wnt inhibitory factor (Wif) domains in the case of Ryk receptors and by CRD domains in the case of Ror receptors (Forrester et al., 20”
• Proximal events in Wnt signal transduction (2009, background): “This functional connection is supported by in vitro experiments showing that Wnt5a interacts with Ror2 and that these two proteins synergistically activate JUN N-terminal kinase (JNK) in cultured cell”
• Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context (2006, methodology): “pcDNA3-mRor2 and mRor2DCRD constructs were obtained from the Minami lab [23].”
• Function and biological roles of the Dickkopf family of Wnt modulators (2006, background): “Comparing Dkk1 to dominant-negative Lrp6 or to other receptor antagonists such as Wise may reveal Lrp6-independent functions of Dkks. JNK activation may be one such b-catenin-independent effect of blocking Wnt-LRP6 signaling.”
• Mechanisms of intercellular Wnt transport (2019, background): “PDGFRα + pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo.”