Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex.

By Nora D. Volkow, Linda Chang, Gene-Jack Wang, J. S. Fowler, Y-S. Ding, M. Sedler, Jean Logan, D. Franceschi, J. Gatley, R. Hitzemann and 3 more. American Journal of Psychiatry, 2001

967 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Epidemiology, Toxicology

View Paper: https://www.semanticscholar.org/paper/aef2ae6c983fa0afc1777ec5e9d0e80468583cb0

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In Cellular and Molecular Neuroscience

In Epidemiology

In Toxicology

Nora D. Volkow

Citations in the corpus

The addicted human brain viewed in the light of imaging studies: brain circuits and treatment strategies. (2004, neutral): “3) (Volkow et al., 1993; Volkow et al., 2001).”
Exposure to appetitive food stimuli markedly activates the human brain (2004, result): “Since our previous studies in drug-addicted subjects showed an association between decreases in DA D2 receptors and metabolism in OFC (Volkow et al., 1993, 2001), further studies are warranted to assess if indeed there are abnormalities in the OFC in obese subjects.”
The addicted human brain: insights from imaging studies. (2003, background): “In detoxified drug abusers, the decreased activity in the OFC is associated with reductions in the numbers of DA D2 receptors in striatum (35, 36).”
The Brain on Drugs: From Reward to Addiction. (2015, methodology): “Repeated exposure to different types of drugs has been associated with downregulation of D2R in striatum (Nader et al., 2006; Thanos et al., 2001; Volkow et al., 2001a).”
Impulsivity, compulsivity, and top-down cognitive control. (2011, neutral): “There is little doubt that chronic drug abuse in humans is associated with substantial structural and metabolic changes in several cortical areas, including lateral PFC and the orbitofrontal cortex (Porrino et al., 2007; Robbins et al., 2008; Volkow et al., 2001).”
A review of the clinical pharmacology of methamphetamine. (2009, background): “Abnormalities include inflammation [102], reduced neuronal density [103] and reduced density of dopaminergic markers such as DAT [67,104,105], D2 receptor [106], VMAT-2 [107] and the serotonergic marker SERT [108].”
Impulsivity as a vulnerability marker for substance-use disorders: review of findings from high-risk research, problem gamblers and genetic association studies. (2008, background): “A series of studies by Volkow and colleagues have shown that addictions to a range of substances are reliably associated with reduced dopamine D2 receptor density in the striatum (Volkow et al., 1993, 1996, 2001; Wang et al., 1997).”
Major physical and psychological harms of methamphetamine use. (2008, background): “evidence of remission in the months following cessation of methamphetamine use [94,95].”
Neurocognitive Effects of Methamphetamine: A Critical Review and Meta-analysis (2007, background): “…above, a number of studies have shown relationships between duration of MA use and extent of dopaminergic dysfunction (Sekine et al. 2001, 2003; Volkow et al. 2001c), as well as at least partial recovery of dopamine terminal function, brain metabolism, and rCBF with extended abstinence (e.g.,…”
Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. (2002, background): “Moreover, the lower levels of striatal D2 receptors were found to be associated with lower metabolism in the orbitofrontal cortex and anterior cingulate gyrus in cocaine addicted subjects (58) (Figure 5) and in the orbitofrontal cortex in methamphetamine abusers (62).”
Disorders of compulsivity: a common bias towards learning habits (2014, positive): “Methamphetamine dependence is also associated with lower striatal D2 receptor availability correlating with lower metabolism in the OFC (25).”