The IKK NF-κB system: a treasure trove for drug development

By M. Karin, Yumi Yamamoto, Q. M. Wang. Nature reviews. Drug discovery, 2004

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Natural polyphenols: An overview (2017, background): “Green tea flavanols reported in animal models have great effects and anti-cancer properties([63]) on human cell lines([64]) and in human intervention studies.”
Elucidating mechanisms of drug-induced toxicity (2005, background): “The nuclear factor-κB (NF-κB) transcriptional regulatory system is essential to the control of inflammation and cell survival, and is a target for modulation by drug”
Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks (2004, background): “Selective IKK inhibitors appear as the most promising and most advanced strategy (Karin et al., 2004).”
Good cop, bad cop: the different faces of NF-κB (2006, background): “To date, the favored therapeutic target of researchers and the pharmaceutical industry has been IKKb, the kinase principally responsible for IkBa phosphorylation in response to inflammatory and many other stimuli.(5,6) However, IKKa”
Role of tumor-associated macrophages in tumor progression and invasion (2006, background): “These findings propose NF-κB as a possible target for development of anti-cancer treatments and clinical trials with drugs that block NF-κB are currently in progress with promising results [28, 29 ].”