The microbiome and innate immunity

By Christoph A. Thaiss, N. Zmora, M. Levy, Eran Elinav. Nature, 2016

1,737 citations recorded by the source corpus.

Subfields: Immunology, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/adf5c39326b033afcc3df08f722a87716242d227

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Citations in the corpus

Homeostatic immunity and the microbiota (2017, positive): “Additionally, intestinal epithelial cells are also influenced indirectly by the microbiota, via cytokine production by innate and adaptive immune cells induced by microbial colonization (reviewed in (Thaiss et al., 2016).”
COVID-19: immunopathogenesis and Immunotherapeutics (2020, background): “There is a crosstalk between immune homeostasis and microbe in several diseases.(56) (1,3)-β-D-glucan, a well-known polysaccharide, is a key structural component of the fungal cell wall.”
The Human Gut Microbiome: From Association to Modulation. (2018, neutral): “…intricately and 221 reciprocally linked to both the innate and adaptive immune system (reviewed by Belkaid and 222 Hand, 2014; Hooper et al., 2012; Thaiss et al., 2016), though it has remained challenging to 223 quantify the immune system’s impact in shaping the gut microbiome independently of…”
Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism (2018, background): “PXR-deficient mice exhibit a leaky gut and reduced expression of Muc2 in the small intestine (Venkatesh et al., 2014).”
Disentangling Interactions in the Microbiome: A Network Perspective (2016, background): “Microbiome interactions are of course not limited to the immediate microbial community, but also occur between the microbes and their hosts, where they have been shown to play key roles in the development, metabolism, homeostasis, and immunity of their hosts [1,2].”
Mechanisms and consequences of intestinal dysbiosis (2017, background): “The trillions of microbes colonizing the gastrointestinal tract influence local and systemic processes such as nutrient transformation [1], vitamin supply [2], maturation of mucosal immunity [3, 4], gut-to-brain communication [5], and even tumor progression [6].”
Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome (2018, background): “, 2016), the training and modulation of the immune system (Kau et al., 2011; Thaiss et al., 2016), and protection against pathogenic organisms (Buffie and Pamer, 2013).”
Human gut microbiota in health and disease: Unveiling the relationship (2022, background): “Innate immunity deals with the physical barrier of the epithelia, specialized cells, and circulating chemicals to immediately identify a wide assortment of foreign antigens and eradicate them (Thaiss et al., 2016).”