COVID-19: immunopathogenesis and Immunotherapeutics

By Shasha Liu, Jinyan Liu, Zhixin Zhang, X. Wan, Bo Huang, Youhai H. Chen, Yi Zhang. Signal Transduction and Targeted Therapy, 2020

755 citations recorded by the source corpus.

The recent novel coronavirus disease (COVID-19) outbreak, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is seeing a rapid increase in infected patients worldwide. The host immune response to SARS-CoV-2 appears to play a critical role in disease pathogenesis and clinical manifestations. SARS-CoV-2 not only activates antiviral immune responses, but can also cause uncontrolled inflammatory responses characterized by marked pro-inflammatory cytokine release in patients with severe COVID-19, leading to lymphopenia, lymphocyte dysfunction, and granulocyte and monocyte abnormalities. These SARS-CoV-2-induced immune abnormalities may lead to infections by microorganisms, septic shock, and severe multiple organ dysfunction. Therefore, mechanisms underlying immune abnormalities in patients with COVID-19 must be elucidated to guide clinical management of the disease. Moreover, rational management of the immune responses to SARS-CoV-2, which includes enhancing anti-viral immunity while inhibiting systemic inflammation, may be key to successful treatment. In this review, we discuss the immunopathology of COVID-19, its potential mechanisms, and clinical implications to aid the development of new therapeutic strategies against COVID-19.

Subfields: Infectious Diseases, Neurology

View Paper: https://www.semanticscholar.org/paper/16f890c698de6231413ac97ea5685256a0d5d716

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  1. Weiming Zhuang
  2. Chen Chen
  3. Jie M. Zhang
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