Drusen associated with aging and age‐related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease

By R. Mullins, S. Russell, Don H. Anderson, G. Hageman. The FASEB Journal, 2000

939 citations recorded by the source corpus.

Subfields: Ophthalmology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/adefa7cbd2b9a6b20477323124bdd71b7552e64a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Ophthalmology

1. O. Strauß
2. M. Zarbin
3. Don H. Anderson
4. L. V. Johnson
5. G. Hageman
6. I. Bhutto
7. G. Lutty
8. Arunkumar Rajendran

In Radiology, Nuclear Medicine and Imaging

1. O. Strauß
2. L. V. Johnson
3. Arunkumar Rajendran
4. M. Zarbin
5. Palanivel Karthigaikumar
6. Don H. Anderson
7. G. Hageman

Citations in the corpus

• The retinal pigment epithelium in visual function. (2005, background): “Drusen is the most important symptom of age-related macular degeneration and consists of basal laminar deposits that are located between RPE and Bruch’s membrane and basal linear deposits that are located inside Bruch’s membrane.”
• Para-inflammation in the aging retina. (2009, background): “…aging human Bruch’s membrane (Glenn et al., 2009; Handa et al., 1999) and in drusen of eyes with AMD (Hollyfield et al., 2003; Yamada et al., 2006). b-amyloid is also detected in drusen and is one of the main components of drusen (Anderson et al., 2004; Crabb et al., 2002; Mullins et al., 2000).”
• Inflammation and its role in age-related macular degeneration (2016, background): “Subretinal drusen resemble the extracellular deposits found in Alzheimer’s disease, amyloidosis, atherosclerosis, elastosis, and dense deposit disease [38, 206, 207].”
• Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex (2012, background): “CRP immunoreactivity has also been identified in ocular drusen and other sub-RPE deposits (Anderson et al., 2002; Mullins et al., 2000).”
• Aptamers as therapeutics (2010, background): “ARC1905 binds to complement component 5 (C5), which is thought to play a role in AmD because it is pro-inflammatory and has been found in retinal deposits of patients with AmD 82 .”
• Current concepts in the pathogenesis of age-related macular degeneration. (2004, background): “Most of the molecular constituents of drusen are synthesized by RPE, neural retina, or choroidal cells, but some are derived from extraocular sources.(56,127,136,176,177,182) Several investigators(183,184) have noted that drusen tend to be distributed near the collecting venules of choriocapillaris ”
• Multi-retinal disease classification by reduced deep learning features (2017, background): “Retinal-based diseases are becoming common among all ages, which reduce the capability of eye to see clearly, due to the blurred visualization and sometimes a complete vision loss [1].”