Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies.

2,340 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Multi-site genetic analysis of diffusion images and voxelwise heritability analysis: A pilot project of the ENIGMA–DTI working group (2013, methodology): “Large meta-analytic studies have been widely used to estimate the genetic influence of behavioral traits (Bezdjian et al., 2011; Malouff et al., 2008), and to reveal the genetic complexity of disease (Sullivan et al., 2003).”
Dysconnection in Schizophrenia: From Abnormal Synaptic Plasticity to Failures of Self-monitoring (2009, background): “Dysconnectivity due to impaired modulation of NMDARdependent synaptic plasticity is consistent with the fact that schizophrenia cannot be explained by genetics alone but only by interactions between genes and environment.(49) In a recent article,(25) we assessed the relative evidence for these 2 mec”
A polygenic burden of rare disruptive mutations in schizophrenia (2014, background): “Genetic studies of schizophrenia (MIM: 181500) have demonstrated a substantial heritability (Sullivan et al., 2003; Lichtenstein et al., 2009) that reflects common and rare alleles at many loci.”
Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment (2023, background): “Environmental factors Although the heritability of schizophrenia is substantial at around 80% [105], even identical twins tend to be discordant for the disorder, underlining the importance of environmental influences [106].”