Temporally precise in vivo control of intracellular signalling

By Raag D. Airan, K. Thompson, Lief Ericsson Fenno, H. Bernstein, Karl Deisseroth. Nature, 2009

690 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ad3532cf661dfd1a77746eba8718f8ef8510df79

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In Cellular and Molecular Neuroscience

In Molecular Biology

Citations in the corpus

Natural neural projection dynamics underlying social behavior. (2014, positive): “We employed the OptoXR approach (Airan et al., 2009) to engineer direct optical control of D1R–mediated Gs signaling by replacing the intracellular loops of rhodopsin with those of D1R to form a chimeric Opto-D1 (Fig.”
The Development and Application of Optogenetics (2011, methodology): “These proteins are referred to as optoXRs (Airan et al. 2009).”
Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. (2009, neutral): “in Transgenic Mice Expressing Evolved”
Molecular and cellular approaches for diversifying and extending optogenetics. (2010, methodology): “…reward, as well as to probe the operation of neural circuits important in a number of brain diseases including Parkinson’s disease and epilepsy (Adamantidis et al., 2007; Airan et al., 2009; Cardin et al., 2009; Gradinaru et al., 2009; Sohal et al., 2009; Tønnesen et al., 2009; Tsai et al., 2009).”
Optogenetic investigation of neural circuits underlying brain disease in animal models (2012, background): “activation of D1R- or D2R-expressing NAc neurons shows differential effects on cocaineconditioned place preference (4)(113).”
Optogenetic tools for analyzing the neural circuits of behavior (2011, methodology): “Some of these tools have been utilized to control behavior in living animals, for example restoring photosensitivity to the blind retina or enabling silencing of neural activity in the spinal cord [38,39], or driving neurons involved with reinforcing behavior [43].”