The Beclin 1 interactome

By Congcong He, Beth Levine. Current Opinion in Cell Biology, 2010

665 citations recorded by the source corpus.

The mammalian ortholog of yeast Atg6/Vps30, Beclin 1, is an essential autophagy protein that has been linked to diverse biological processes, including immunity, development, tumor suppression, lifespan extension, and protection against certain cardiac and neurodegenerative diseases. In recent years, major advances have been made in identifying components of functionally distinct Beclin 1/class III phosphatidylinositol 3-kinase complexes, in characterizing the molecular regulation of interactions between Beclin 1 and the autophagy inhibitors, Bcl-2/BcL-XL, and in uncovering a role for viral antagonists of Beclin 1 in viral pathogenesis. The rapidly growing list of components of the ‘Beclin 1 interactome’ supports a model in which autophagy, and potentially other membrane trafficking functions of Beclin 1, are governed by differential interactions with different binding partners in different physiological or pathophysiological contexts.

Subfields: Cell Biology, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ac57f2e2db30a0617aa5d5822bcbbee21eff9580

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Citations in the corpus

Exercise–induced BCL2–regulated autophagy is required for muscle glucose homeostasis (2012, background): “BCL2 is an anti-apoptotic and anti-autophagy protein that inhibits autophagy through a direct interaction with the BH3 domain of the autophagy protein beclin 1 at the endoplasmic reticulu”
Cell Death Signaling. (2015, background): “Both pathways are initiated by a single E1-ligase-like activating enzyme, ATG7, recruited to the phagophore through PI3P generated by the initiation complex.”
Multiple Functions of BCL-2 Family Proteins (2013, background): “Recent studies indicate that in addition to their apoptotic roles, members of BCL-2 family proteins also regulate autophagy (Levine et al. 2008, 2011; He and Levine 2010; Kang et al. 2011).”
Autophagy-deficient mice develop multiple liver tumors. (2011, background): “However, these factors are not specific for autophagy and are considered to have multiple functions, such as involvement in the endocytic pathway (Funderburk et al. 2010; He and Levine 2010; Thoresen et al. 2010), which has many roles in tumorigenesis (Mosesson et al.”
Autophagy Failure in Alzheimer's Disease – Locating the Primary Defect (2011, background): “In further support for impairment in the early stages of autophagy, levels of the autophagy-related protein beclin-1, a component of the PI3 kinase complex essential for autophagosome formation (Funderburk et al., 2010; He and Levine, 2010), have been reported to be reduced, along with PI3K, in brai”
Autophagy‐based unconventional secretory pathway for extracellular delivery of IL‐1β (2011, background): “The principal components of the autophagic signalling and execution machinery are (i) a protein kinase network including Tor, AMPK, and Ulk1/2 (Egan et al, 2011; Kim et al, 2011), (ii) lipid kinases, principally the class III phosphatidylinositol 3kinase hVPS34 (Kihara et al, 2001) and potentially c”
Autophagy in mammalian development and differentiation (2010, background): “Beclin 1, a component of class III phosphatidylinositol-3-OH kinase (PI(3)K) complexe”
Compromised MAPK signaling in human diseases: an update (2015, background): “Beclin-1 is a major component of autophagosomes (He and Levine 2010), and its abundance appears to be reduced in the brain of AD patients (Jaeger et al.”
The regulation of autophagy – unanswered questions (2011, background): “How is the function of PtdIns3K regulated? The mammalian class III PtdIns3K has been divided into different types of complex based on the interaction of its core components (beclin 1, Vps34 and Vps15) with different interacting proteins (Funderburk et al., 2010; He and Levine, 2010).”
Autophagy and the integrated stress response (2010, positive): “However, ULK1 can phosphorylate Ambra1 (Di Bartolomeo et al., 2010), a component of the Beclin 1/Class III PI3K complex (He and Levine, 2010) (Figure 1A).”
Principles and Current Strategies for Targeting Autophagy for Cancer Treatment (2011, background): “Types of autophagy vary depending on the stimulus and requirement for substrate degradation (4, 31, 32).”
PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity (2012, background): “It interacts with several cofactors to regulate the class III phosphatidylinositol 3kinase (PI3KC3) and promote formation of Beclin 1-PI3KC3 core complexes, thereby inducing autophagy (39, 40).”