A MicroRNA Feedback Circuit in Midbrain Dopamine Neurons

By Jongpil Kim, Keiichi Inoue, J. Ishii, W. Vanti, Sergey V. Voronov, E. Murchison, Gregory J. Hannon, A. Abeliovich. Science, 2007

1,217 citations recorded by the source corpus.

Subfields: Cancer Research, Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ac4c2d6ff9b8d7af37b07b87bce2c45cd23ff6ce

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In Cancer Research

In Cellular and Molecular Neuroscience

Peter T. Nelson

In Molecular Biology

Citations in the corpus

The Expression of MicroRNA miR-107 Decreases Early in Alzheimer's Disease and May Accelerate Disease Progression through Regulation of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 (2008, methodology): “These reporter constructs have been useful in previous description of miRNA:mRNA interactions (Kiriakidou et al., 2004, 2005, 2007; Nelson et al., 2004).”
MicroRNAs in Common Human Diseases (2012, background): “Deregulation of miR-133b expression may contribute to the pathogenesis of PD, as the miR-133b-Pitx3 feedback loop is essential for maintaining dopaminergic neurons in the brain [92].”
Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth (2012, neutral): “Studies in zebrafish and rodents demonstrate that microRNA 133b (miR-133b) is expressed in midbrain dopaminergic neurons and regulates the production of tyrosine hydroxylase and the dopamine transporter [18–20] in patients with Parkinson’s disease [20].”
The sequential action of miR156 and miR172 regulates developmental timing in Arabidopsis. (2009, neutral): “There is growing evidence from animal systems that miRNAregulated transcription factors frequently regulate the transcription of their cognate miRNAs (Fazi et al., 2005; Johnson et al., 2005; Kim et al., 2007; Varghese and Cohen, 2007).”
Translational control of long-lasting synaptic plasticity and memory. (2009, neutral): “For example, inactivation of Dicer in forebrain, Purkinje, and dopaminergic neurons results in microcephaly, progressive neurodegeneration , and increased apoptosis and neurodegeneration, respectively (Davis et al., 2008; Hebert and De Strooper, 2007; Kim et al., 2007; Schaefer et al., 2007).”
The bi-functional microRNA miR-9/miR-9* regulates REST and CoREST and is down-regulated in Huntington’s Disease (2008, background): “Given their essential role in modulation of cellular processes such as cell fate, identity, and function (Sempere et al., 2004; Kim et al., 2007; Makeyev et al., 2007), we screened a panel of predicted REST-regulated miRNAs (Jothi et al., 2008) in samples collected from healthy control and HD…”
Non-coding RNAs in human disease (2011, background): “For instance, the importance of miRNAs for terminal differentiation and the maintenance of many neuronal types has been demonstrate”
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression (2008, background): “The hypothesis that miRNA pathways could contribute to neurodegeneration is appealing (18) and has been tested to a certain degree in Drosophila (19) and mouse models (18, 20, 21) in which all miRNAs are lacking.”
The widespread regulation of microRNA biogenesis, function and decay (2010, background): “PITX3 stimulates transcription of miR-133b, which in turn suppresses PITX3 expressio”