Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released.

By J. Italiano, Jennifer L. Richardson, S. Patel-Hett, E. Battinelli, A. Zaslavsky, S. Short, S. Ryeom, J. Folkman, G. Klement. Blood, 2008

894 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Hematology, Urology

View Paper: https://www.semanticscholar.org/paper/ab90a3a3abf18a953fb191b8c17984ce84c4ba1a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. B. Felding‐Habermann
2. Laurie J. Gay

In Hematology

1. P. Doglioli
2. B. Felding‐Habermann
3. D. M. Dohan Ehrenfest
4. G. Sammartino
5. Laurie J. Gay
6. G. M. de Peppo

In Urology

1. P. Doglioli
2. D. M. Dohan Ehrenfest
3. G. Sammartino
4. G. M. de Peppo

Citations in the corpus

• Slow release of growth factors and thrombospondin-1 in Choukroun's platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies (2009, background): “Additionally, since the platelets present into the concentrates contain similar quantity of both angiogenesis stimulators (VEGF, bFGF) and inhibitors (endostatin, TSP-1; Italiano et al. 2008), the VEGF produced by the leucocytes might be very important in promoting angiogenesis.”
• The incredible journey: From megakaryocyte development to platelet formation (2013, background): “In a pivotal study, Junt et al. (2007) observed proplatelet formation in real time in the bone marrow of mice by multiphoton intravital microscopy.”
• Platelet secretion: From haemostasis to wound healing and beyond (2015, neutral): “Immunogold labelling by the Italiano group also showed α-granule populations containing either endostatin or VEGF but not both [125].”
• Contribution of platelets to tumour metastasis (2011, background): “For example, granules laden with VEGF are selectively released after ligation of protease-activated receptor 1 (PAR1), and granules containing endostatin are released on PAR4 activatio”
• Platelets and the immune continuum (2011, background): “Although it was previously thought that these various molecules were packaged indiscriminately into one consistent population of α-granules that underwent simultaneous release, recent work suggests that platelets contain heterogeneous populations of α-granules that undergo differential patterns of r”