Platelet secretion: From haemostasis to wound healing and beyond
By Ewelina Gołębiewska, A. Poole. Blood reviews, 2015
833 citations recorded by the source corpus.
Upon activation, platelets secrete more than 300 active substances from their intracellular granules. Platelet dense granule components, such as ADP and polyphosphates, contribute to haemostasis and coagulation, but also play a role in cancer metastasis. α-Granules contain multiple cytokines, mitogens, pro- and anti-inflammatory factors and other bioactive molecules that are essential regulators in the complex microenvironment of the growing thrombus but also contribute to a number of disease processes. Our understanding of the molecular mechanisms of secretion and the genetic regulation of granule biogenesis still remains incomplete. In this review we summarise our current understanding of the roles of platelet secretion in health and disease, and discuss some of the hypotheses that may explain how platelets may control the release of its many secreted components in a context-specific manner, to allow platelets to play multiple roles in health and disease.
Subfields: Genetics, Hematology
View Paper: https://www.semanticscholar.org/paper/e37b6bc375a436dbcfeb348637580c46bdd89bad
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Citations in the corpus
- Wound Healing: A Cellular Perspective. (2019, background): “These intracellular granules secrete more than 300 active substances (149) such as ADP, serotonin, calcium, and histamine that are required for platelet activation as well as vWF and integrins, which are required for primary and secondary hemostasis (22).”
- Wound healing: cellular mechanisms and pathological outcomes (2020, background): “Platelets are crucial in the recruitment of immune cells to the injury site, by either directly capturing immune cells in the eschar, or by releasing a secretome of chemokine attractants upon degranulation [6].”
- Blood-Contacting Biomaterials: In Vitro Evaluation of the Hemocompatibility (2018, neutral): “, nitric oxide (NO) and prostaglandin I2 (PGI2) (Brass et al., 2013; Golebiewska and Poole, 2015; Frohlich, 2016).”
- SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19 (2020, background): “Platelets are an important source of coagulation factors V and XIII in α granules, and serve as adhesion sites for coagulation factors activation via their surface exposure of phosphatidylserine (PS) [58].”