Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

By A. Pasquinelli, B. Reinhart, Frank J. Slack, M. Martindale, M. Kuroda, Betsy Maller, D. Hayward, E. Ball, B. Degnan, P. Müller and 9 more. Nature, 2000

2,685 citations recorded by the source corpus.

Subfields: Aging, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/aaef86016a0a2e9ad44803875035b81c34d8dff4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

In Molecular Biology

Citations in the corpus

bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. (2003, background): “Hedgehog and Dpp signaling (e.g., Pasquinelli et al., 2000).”
Non–coding RNA genes and the modern RNA world (2001, background): “Surprisingly,Amy Pasquinelli et al.(87) showed that let-7 was almost 100% conserved and expressed as a small 21nucleotide RNA in all bilaterally symmetrical animals that were tested, including human, mouse, chicken, polychaete worms and flies, but not in cnidarians (jellyfish) or poriferans (sponges”
Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. (2008, background): “…ª2008 Elsevier In let-7 RNA, highly conserved in bilaterian animals, controls developmental timing (Grosshans et al., 2005; Meneely and Herman, 1979; Pasquinelli et al., 2000; Reinhart et al., 2000). let-7 also functions as a tumor suppressor by targeting RAS, HMGA2, and c-Myc (Johnson et al.,…”
Noncoding RNA gene detection using comparative sequence analysis (2001, background): “Recent discoveries have included RNAs involved in dosage compensation and imprinting [5], numerous small nucleolar RNAs involved in RNA modification and processing [6–8], and small riboregulatory RNAs controlling translation and/or stability of target mRNAs [9,10].”
Gene silencing in plants using artificial microRNAs and other small RNAs. (2008, background): “elegans, let-7, and the discovery of let-7 homologs in the genomes of many other animals including humans (Pasquinelli et al., 2000; Reinhart et al., 2000).”
A biochemical framework for RNA silencing in plants. (2003, background): “miRNAs are produced by Dicer cleavage of stem–loop precursor RNA transcripts (pre-miRNAs); the miRNA can reside on either the 5 or 3 side of the doublestranded stem (Lee et al. 1993; Pasquinelli et al. 2000; Lagos-Quintana et al. 2001; Lau et al. 2001; Lee and Ambros 2001).”
MicroRNAs in Common Human Diseases (2012, background): “demonstrated that the let-7 sequence was highly conserved across the evolutionary spectrum [5], biologists started to realize that this tiny RNA molecule may have a big role to play in humans as well [6].”
The Genetic Signatures of Noncoding RNAs (2009, background): “elegans, not in other organisms, despite the former being not only highly conserved in sequence and expression pattern throughout metazoan evolution [139], but also fundamental to normal and abnormal developmental processes [140– 142], as are many other miRNAs [143].”
Computational and experimental identification of C. elegans microRNAs. (2003, methodology): “The best described targets comprise two imperfect duplexes between let-7 and the 3′ UTR of lin-41, and seven imperfect duplexes between lin-4 and the 3′-UTR of lin-14 (Lee et al., 1993; Reinhart et al., 2000; Wightman et al., 1993; Slack et al., 2000; Pasquinelli et al., 2000).”