bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila.

By J. Brennecke, D. Hipfner, Alexander Stark, Robert B. Russell, Stephen M Cohen. Cell, 2003

2,130 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9c5869d05e0634626712032625912354e0537108

How researchers see this paper

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In Cancer Research

1. David P. Bartel
2. Phillip D. Zamore
3. V. Narry Kim
4. Scott M. Hammond
5. Carlo Maria Croce
6. Nikolaus Rajewsky
7. Frank J. Slack
8. Thomas Tuschl

In Molecular Biology

1. David P. Bartel
2. Phillip D. Zamore
3. V. Narry Kim
4. Nikolaus Rajewsky
5. Carlo Maria Croce
6. Scott M. Hammond
7. Thomas Tuschl
8. Gregory J. Hannon

Citations in the corpus

• Prediction of mammalian microRNA targets. (2003, methodology): “elegans let-7 miRNA (Lee et al., 1993; Wightman rate training and test sets of miRNAs. et al., 1993; Moss et al., 1997; Reinhart et al., 2000; TargetScan was initially applied using two sets of Abrahante et al., 2003; Brennecke et al., 2003; Lin et al., miRNAs: a nonredundant pan-mammalian set of 79”
• Programmed Cell Death in Animal Development and Disease (2011, neutral): “RHG genes are also the target for microRNA regulation (Brennecke et al., 2003).”
• Real-time quantification of microRNAs by stem–loop RT–PCR (2005, background): “Specific roles include the regulation of cell proliferation and metabolism (22), developmental timing (23,24), cell death (25), haematopoiesis (26), neuron development (27), human tumorigenesis (28) and DNA methylation and chromatin modification (29).”
• Human embryonic stem cells express a unique set of microRNAs. (2004, background): “Another example is bantam RNA from Drosophila melanogaster, which is expressed in a temporal and tissue-specific manner during development, suppressing apoptosis and stimulating cell proliferation by inhibiting translation of hid mRNA (Brennecke et al., 2003).”
• Computational prediction of miRNAs in Arabidopsis thaliana. (2005, background): “…products (Aukerman and Sakai 2003) However, a reduction in the level of the full-target transcripts was not observed using RNA gel-blot analysis even in plants overexpressing the miR172 RNA, and the actual regulation was found to be at the level of translation (Aukerman and Sakai 2003; Chen 2004).”
• Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. (2007, positive): “In some cases, they function to ‘‘fine-tune’’ physiologic events, but in others they function as molecular ‘‘switches’’ (Brennecke et al., 2003; Johnston and Hobert, 2003; Kwon et al., 2005; Lee et al., 1993; Moss et al., 1997; Reinhart et al., 2000; Sokol and Ambros, 2005; Wightman et al., 1993).…”
• Human MicroRNA Targets (2004, background): “In D. melanogaster, miR-14 has a role in apoptosis and fat metabolism (Xu et al. 2003) and the bantam miRNA targets the gene hid involved in apoptosis and growth control (Brennecke et al. 2003).”