A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen.

By Jason Moffat, D. Grueneberg, Xiaoping Yang, S. Kim, A. Kloepfer, G. Hinkle, Bruno Piqani, T. Eisenhaure, Biao Luo, J. Grenier and 9 more. Cell, 2006

1,888 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/aa51dc8b9d8341e8c3e92316686ae291b435b09d

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Citations in the corpus

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. (2006, background): “A previous study found that amino acids have a particularly important role in regulating trophoblast differentiation in an mTOR-dependent manner ( Martin and Sutherland, 2001 ).”
Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles (2013, methodology): “Lentiviruses expressing shRNA and a puromycin resistance gene were obtained from the RNAi consortium (TRC) and produced as described previously (Moffat et al., 2006).”
Densely interconnected transcriptional circuits control cell states in human hematopoiesis (2011, positive): “The concentration of Epo was increased to 3 IU/ml on day 7. shRNA Experiments Oligonucleotides encoding shRNAs were cloned into pLKO.1 as described previously (Moffat et al., 2006).”
Rab27a and Rab27b control different steps of the exosome secretion pathway (2010, methodology): “Lentiviruses expressing shRNA were obtained from the RNAi consortium (TRC) and produced as described previousl”