Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers.

By Ryunosuke Kogo, Teppei Shimamura, K. Mimori, K. Kawahara, Seiya Imoto, T. Sudo, F. Tanaka, K. Shibata, A. Suzuki, S. Komune and 2 more. Cancer Research, 2011

1,267 citations recorded by the source corpus.

The functional impact of recently discovered long noncoding RNAs (ncRNAs) in human cancer remains to be clarified. One long ncRNA which has attracted attention is the Hox transcript antisense intergenic RNA termed HOTAIR, a long ncRNA expressed from the developmental HOXC locus located on chromosome 12q13.13. In cooperation with Polycomb complex PRC2, the HOTAIR long ncRNA is reported to reprogram chromatin organization and promote breast cancer metastasis. In this study, we examined the status and function of HOTAIR in patients with stage IV colorectal cancer (CRC) who have liver metastases and a poor prognosis. HOTAIR expression levels were higher in cancerous tissues than in corresponding noncancerous tissues and high HOTAIR expression correlated tightly with the presence of liver metastasis. Moreover, patients with high HOTAIR expression had a relatively poorer prognosis. In a subset of 32 CRC specimens, gene set enrichment analysis using cDNA array data revealed a close correlation between expression of HOTAIR and members of the PRC2 complex (SUZ12, EZH2, and H3K27me3). Our findings suggest that HOTAIR expression is associated with a genome-wide reprogramming of PRC2 function not only in breast cancer but also in CRC, where upregulation of this long ncRNA may be a critical element in metastatic progression.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/aa19a3a5e394b6d191b499b5f426e852e1375bf6

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Citations in the corpus

Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs (2012, background): “This includes breast cancer (53), colorectal cancer (81), prostate cancer (82), hepatocellular carcinoma (83–85), leukemia (86,87), melanoma (88) and possibly others (76,89).”
Long non-coding RNAs: a new frontier in the study of human diseases. (2013, background): “Notably, HOTAIR is significantly overexpressed in many cancers, including breast cancer, hepatocellular cancer, colorectal cancer and laryngeal squamous cell carcinoma [63–65].”
Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer (2016, background): “breast cancer [12], colorectal cancer [9,13], liver cancer [14,15], and leukemia [9,16].”
Long Noncoding RNAs: Past, Present, and Future (2013, background): “Review 655 (Gupta et al. 2010), liver (Z. Yang et al. 2011), colorectal (Kogo et al. 2011), gastrointestinal (Niinuma et al. 2012), and pancreatic (Kim et al. 2012) cancers and is proposed to increase tumor invasiveness and metastasis (Gupta et al. 2010).”
Long non-coding RNA (LncRNA) and cancer: a new paradigm (2017, background): “BRCA1, a critical player in DNA damage response and breast cancer, also interacts with EZH2, which in turn interacts with HOTAIR (54, 57, 58).”
Pathway-based personalized analysis of cancer (2013, neutral): “(32), 89 and 141 samples, respectively (SI Appendix).”
Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer (2014, background): “It is evident that nuclear HOTAIR can target polycomb repressive complex 2, altering H3K27 methylation and gene expression patterns across the genome [10,11].”