Long non-coding RNA (LncRNA) and cancer: a new paradigm
By A. Bhan, Milad Soleimani, Subhrangsu S. Mandal. Cancer Research, 2017
2,362 citations recorded by the source corpus.
In addition to mutations or aberrant expression in the protein coding genes, mutations and misregulation of non-coding RNAs, in particular long noncoding RNAs (lncRNA), appear to play major roles in cancer. Genome-wide association studies (GWAS) of tumor samples have identified a large number of lncRNAs associated with various types of cancer. Alterations in lncRNA expression and their mutations promote tumorigenesis and metastasis. LncRNAs may exhibit tumor suppressive and promoting (oncogenic) functions. Due to their genome-wide expression patterns in a variety of tissues and their tissue-specific expression characteristics, lncRNAs hold strong promise as novel biomarkers and therapeutic targets for cancer. In this article, we have reviewed the emerging functions and association of lncRNAs in different types of cancer and discussed their potential implications in cancer diagnosis and therapy.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/e5156419c49266fe24b0d422f3e4a7e248bbd5c1
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In Cancer Research
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Citations in the corpus
- Long Non-Coding RNA in the Pathogenesis of Cancers (2019, background): “H19 overexpression is associated with carcinogenesis from early stages to metastasis, reduced disease-free survival (DFS) time, and poor prognosis in LC [4,41,46,67].”
- The Need for Multi-Omics Biomarker Signatures in Precision Medicine (2019, background): “This includes alterations in DNA methylation [55], histone modifications [56], and expression of miRNAs [57] and lncRNAs [58,59].”