Collagen-based cell migration models in vitro and in vivo.

By Katarina Wolf, Stephanie Alexander, V. Schacht, Lisa M. Coussens, U. V. von Andrian, J. van Rheenen, E. Deryugina, Peter Friedl. Seminars in Cell and Developmental Biology, 2009

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Dynamic interplay between the collagen scaffold and tumor evolution (2010, background): “To address these concerns, second harmonic generation using two-photon microscopy has been used in live animals to monitor how epithelial and stromal cells interact with and initiate collagen remodeling to regulate its architecture [36,39,49,78,89,101].”
Application of Collagen Scaffold in Tissue Engineering: Recent Advances and New Perspectives (2016, background): “regulate the morphology, adhesion, migration and differentiation of cells [7,8].”
Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer (2011, methodology): “Similarly, these techniques have been used to monitor the interactions of epithelial and stromal cells with tumors, as well as the initiation of collagen remodeling (Brown et al., 2003; Condeelis and Segall, 2003; Perentes et al., 2009; Wolf et al., 2009).”
Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors. (2012, neutral): “Tumors are heterogeneous in terms of ECM textures (38).”
Cancer invasion and the microenvironment: plasticity and reciprocity. (2011, positive): “The second strategy results from proteolytic breakdown of tissue structures to generate de novo space required for invasion (Wolf et al., 2009; Wolf and Friedl, 2011).”