Application of Collagen Scaffold in Tissue Engineering: Recent Advances and New Perspectives
By Chanjuan Dong, Yonggang Lv. Polymers, 2016
721 citations recorded by the source corpus.
Collagen is the main structural protein of most hard and soft tissues in animals and the human body, which plays an important role in maintaining the biological and structural integrity of the extracellular matrix (ECM) and provides physical support to tissues. Collagen can be extracted and purified from a variety of sources and offers low immunogenicity, a porous structure, good permeability, biocompatibility and biodegradability. Collagen scaffolds have been widely used in tissue engineering due to these excellent properties. However, the poor mechanical property of collagen scaffolds limits their applications to some extent. To overcome this shortcoming, collagen scaffolds can be cross-linked by chemical or physical methods or modified with natural/synthetic polymers or inorganic materials. Biochemical factors can also be introduced to the scaffold to further improve its biological activity. This review will summarize the structure and biological characteristics of collagen and introduce the preparation methods and modification strategies of collagen scaffolds. The typical application of a collagen scaffold in tissue engineering (including nerve, bone, cartilage, tendon, ligament, blood vessel and skin) will be further provided. The prospects and challenges about their future research and application will also be pointed out.
Subfields: Biomaterials, Biomedical Engineering
View Paper: https://www.semanticscholar.org/paper/49e9933be8c9b368184d8e84425ccfa6e09255f4
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Citations in the corpus
- Natural Polymeric Scaffolds in Bone Regeneration (2020, background): “As a major constituent of the ECM in various connective tissues, collagens are the most abundant protein in the human body (25 to 35% of the whole-body protein content), and as a primary component in bone, they are also ideal candidates for 3D scaffold design (Aravamudhan et al., 2013; Dong and Lv, ”
- Fused deposition modelling: Current status, methodology, applications and future prospects (2021, background): “Scaffolds are used as supports for the tissue growth of bone, cartilage, ligaments, skin, blood vessels, nerves and muscle [246].”