β-globin Gene Switching and DNase I Sensitivity of the Endogenous β-globin Locus in Mice Do Not Require the Locus Control Region
By M. Bender, M. Bulger, J. Close, Mark Groudine. 2000
230 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/a9ae3a64d3942e896ef89b0960c321f4e170ac7d
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In Genetics
In Molecular Biology
- G. Felsenfeld
- A. West
- Peter Fraser
- Jeannie T. Lee
- Johnny T Y Kung
- David Colognori
- Howard Y. Chang
- Richard A. Young
Citations in the corpus
- Looping, Linking, and Chromatin Activity: New Insights into β-globin Locus Regulation (2000, background): “The Bender et al. (2000) and Gribnau et al. (2000) reports highlighted here address qualities of site 59 to the d-globin gene.”
- Conserved CTCF Insulator Elements Flank the Mouse and Human β-Globin Loci (2002, methodology): “Of these deletions, only a large deletion of 5HS1 to -6 showed a significant -globin phenotype ( 5 , 13), which was apparently due to the absence of 5HS1 to -4. The other smaller deletions of the 5HS5 region gave a negligible -globin phenotype (4, 14), suggesting that any putative boundary function ”
- Functional and mechanistic diversity of distal transcription enhancers (2011, unknown): “High-level expression of the mammalian b-globin genes in erythroid cells, for example, requires a set of sequence elements termed the locus control region (LCR) that is distributed across a region of 20–30 kb located upstream of the gene cluster (Bender et al., 2000; Moon and Ley, 1990; Grosveld et ”
- Controlling long range genomic interactions at a native locus by targeted tethering of a looping factor (2012, unknown): “The strong induction of b-globin transcription by ZF-Ldb1 or ZFSA implicates an involvement of the LCR and, hence, chromatin looping, because in the absence of the LCR, b-globin transcription is very low (Bender et al., 2000).”
- Long Noncoding RNAs: Past, Present, and Future (2013, background): “…transcription has been seen to occur throughout the globin locus (Ashe et al. 1997) and plays a role in establishing open chromatin domains (Bender et al. 2000; Gribnau et al. 2000) marked by permissive histone modifications Review 659 such as H3K4me2/3 and H3 acetylation (Miles et al.…”
- Long-range chromatin regulatory interactions in vivo (2002, background): “The four mouse β-like globin genes require the distal LCR for high-level expression in erythroid cell”