Conserved CTCF Insulator Elements Flank the Mouse and Human β-Globin Loci

By C. Farrell, A. West, G. Felsenfeld. Molecular and Cellular Biology, 2002

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Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements. (2006, background): “CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1.”
Looping and interaction between hypersensitive sites in the active beta-globin locus. (2002, background): “Since crosslinking values been proposed to act as insulators (Farrell et al., 2002)in brain and in liver are both normalized to the same but include all HS and the promoters/enhancers of thecontrol value, we were concerned about the fact that genes.”
CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus. (2007, unknown): “In mice, three CTCF-binding sites have been identified upstream (HS-85, HS-62, and HS5) and one downstream (3 (cid:1) HS1) of the locus (Farrell et al. 2002; Bulger et al. 2003).”
CTCF mediates long-range chromatin looping and local histone modification in the β-globin locus (2006, unknown): “In mice, three CTCF-binding sites have been identified upstream (HS85, HS-62, and HS5) and one downstream (3 HS1) of the locus (Farrell et al. 2002; Bulger et al. 2003).”
CTCF: Master Weaver of the Genome (2009, unknown): “CTCF-bound 3′HS1 displays strong EB activity in transgene assays (Farrell et al., 2002) and, in principle, could prevent inappropriate LCR activation of downstream olfactory receptor (OR) genes.”