Enzymes involved in the activation and inactivation of vitamin D.

By D. Prosser, Glenville Jones. TIBS -Trends in Biochemical Sciences. Regular ed, 2004

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Nonclassic actions of vitamin D. (2009, background): “There are a number of cytochrome P450 enzymes, both mitochondrial and microsomal, capable of this function (9), although CYP27A1 has received the most study.”
Mutations in CYP24A1 and idiopathic infantile hypercalcemia. (2011, background): “This active form is inactivated by 24-hydroxylase (CYP24A1), an enzyme that is responsible for the five-step 24-oxidation pathway from 1,25-dihydroxyvitamin D3 to calcitroic acid.13,14 CYP24A1 can also break down the precursor, 25-hydroxyvitamin D3, to the inactive metabolite, 24,25-dihydroxyvitamin”
DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27 (2007, background): “Subsequently, 25(OH)D 3 is transported to the kidney, where the most active form, 1,25(OH) 2 D 3 , is generated by the 1-hydroxylase activit”
Vitamin D and human health: lessons from vitamin D receptor null mice. (2008, neutral): “tone after initial 23-hydroxylation (32).”
Pharmacokinetics of vitamin D toxicity. (2008, background): “CYP24A1 plays a critical role in the degradation of both 25-hydroxyvitamin D3 [25(OH)D3] and 1 ,25(OH)2D3 through a side-chain hydroxylation and cleavage pathway known as C-24 oxidation (5).”