Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies.

By Ming Zhang, D. Methot, Veronica Poppa, Y. Fujio, K. Walsh, Charles E. Murry. Journal of Molecular and Cellular Cardiology, 2001

907 citations recorded by the source corpus.

Subfields: Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/a95944cdfbb042bf290c96a963362454fa4b91ff

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Citations in the corpus

Regenerating the heart (2005, background): “Regardless of cell type, multiple studies indicate that ∼90% of cells successfully delivered to the heart die within the first wee”
Improving Viability of Stem Cells During Syringe Needle Flow Through the Design of Hydrogel Cell Carriers (2011, neutral): “Cell injection procedures typically result in a deficit of live cells, with viabilities as low as 1%–32% post-transplantation.(19) Many cell injection studies have focused on the role of the host microenvironment as a contributing factor to low transplanted cell viability.”
Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts (2003, background): “Cell transplantation strategies to replace lost myocardium are limited by the inability to deliver large numbers of cells that resist peritransplantation graft cell deat”
Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts (2007, methodology): “To test this regimen, we induced myocardial infarcts by 60 min of ischemia followed by reperfusion, and cardiomyocytes were transplanted at 4 d postinfarction, when angiogenesis associated with wound repair was at its maximum in this model and survival of grafted rat cardiomyocytes is the longes”
Proangiogenic scaffolds as functional templates for cardiac tissue engineering (2010, background): “Studies show that 50–90% of injected cells are lost by extrusion (1) and that ∼90% of remaining cells die within 1 wk of implantation (2).”
Scaffolds and cells for tissue regeneration: different scaffold pore sizes—different cell effects (2016, methodology): “Additionally, it was shown that around 90 % of transplanted cells die within 1 week and 50–90 % are extruded out of the myocardium (Zhang et al. 2001; Muller-Ehmsen et al. 2002).”