Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet.

By C. Ebato, Toyoyoshi Uchida, M. Arakawa, M. Komatsu, T. Ueno, Koji Komiya, K. Azuma, T. Hirose, Keiji Tanaka, E. Kominami and 3 more. Cell Metabolism, 2008

731 citations recorded by the source corpus.

Subfields: Epidemiology, Pharmacology, Surgery

View Paper: https://www.semanticscholar.org/paper/a934e8c95ade36535ed745b54a94118ffb0c333f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Guido Kroemer
2. N. Mizushima
3. Beth Levine
4. Guillermo Mariño
5. M. Komatsu
6. D. Rubinsztein
7. G. Hotamışlıgil
8. M. Cerf

In Pharmacology

1. Guido Kroemer
2. N. Mizushima
3. M. Komatsu
4. Guillermo Mariño
5. D. Rubinsztein
6. G. Hotamışlıgil
7. Beth Levine
8. Alec C. Kimmelman

In Surgery

1. Guido Kroemer
2. Guillermo Mariño
3. M. Cerf
4. N. Mizushima
5. G. Hotamışlıgil
6. C. Hetz

Citations in the corpus

• Autophagy: Renovation of Cells and Tissues (2011, background): “This process is considered to be an adaptive response, particularly in the presence of insulin resistance (Ebato et al., 2008).”
• The Interplay Between Mitochondrial Dynamics and Mitophagy (2011, background): “AP formation is increased in b-cells under high-fat diet and prediabetic conditions (26).”
• Autophagy in the Cellular Energetic Balance (2011, neutral): “Despite the pronounced phenotype of autophagy blockage in b cells, macroautophagy does not increase in these cells during starvation (Ebato et al., 2008).”
• Beta Cell Dysfunction and Insulin Resistance (2013, background): “Autophagy, a catabolic process that involves the degradation of cellular components through the lysosomal machinery, is important for maintaining normal islet homeostasis and compensatory beta cell hyperplasia in response to high fat dietary intake (Ebato et al., 2008).”
• Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance (2010, background): “Combined with the potential reported role in islet function and survival (Ebato et al., 2008; Jung et al., 2008), the data presented here indicate that autophagy may be a relevant mechanism for the two major pathological arms of type 2 diabetes: impaired insulin secretion and insulin sensitivity.”
• p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation (2016, neutral): “, cardiomyocytes [51], pancreatic β-cells [52], skeletal muscle [53], liver [54] and central nervous system [48]), and species (e.”
• Autophagy and aging. (2011, background): “…diet-induced diabetes; this phenotype can be improved by feeding the antioxidant N-acetylcysteine Insulin-dependent diabetes Jung et al., 2008; Ebato et al., 2008; Wu et al., 2009 No cardiac phenotype in baseline conditions but enhanced susceptibility to acute pressure overload-induced…”