Clonal mesenchymal progenitors from human bone marrow differentiate in vitro according to a hierarchical model.

By A. Muraglia, R. Cancedda, R. Quarto. Journal of Cell Science, 2000

1,089 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/a8b3874665a54c29e7c3e2bd27864a6884224774

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Citations in the corpus

• Human adipose tissue is a source of multipotent stem cells. (2002, background): “However, a recent model has proposed the existence of a hierarchy in the MSC differentiation pathway, with the adipogenic lineage diverging early and the osteogenic lineage a default pathway (Muraglia et al., 2000).”
• Aging of mesenchymal stem cells. (2006, unknown): “– Rat Muraglia et al. (2000) ALP-CFU = Dex Mouse Bergman et al. (1996) ALP = Dex, VitC Rat Dobson et al. (1999) ALP-CFU !”
• Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. (2005, background): “Induction of differentiation into osteoblasts, adipocytes, and chondrocytes under appropriate culture conditions has been demonstrated extensively [7,12,17–22].”
• Bone substitutes in orthopaedic surgery: from basic science to clinical practice (2014, background): “MSC derived from bone marrow showed a high potential for osteogenic differentiation, which has been exploited for cell-based therapy of congenital bone disorders [182–184].”
• Mechanisms involved in the therapeutic properties of mesenchymal stem cells. (2009, background): “Clonal analyses of human MSCs have shown that, at a given moment during cell culture, there are clones able to differentiate into three, two or only one mature cell type assayed, and that the frequency of tripotent clones decreased as the cells were expanded in culture [17].”
• Platelet lysates promote mesenchymal stem cell expansion: A safety substitute for animal serum in cell‐based therapy applications (2005, background): “…IGF-1, and PDGFs are key factors in supporting MSC ex vivo expansion and maintaining their multilineage potential for further differentiation (Gibbons et al., 1995; Cassiede et al., 1996; Hanada et al., 1997; Banfi et al., 2000; Muraglia et al., 2000; Tsutsumi et al., 2001; Walsh et al., 2003).”
• Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy (2004, background): “[42] demonstrated that 30% of the in vitro derived MSC clones exhibited a tri-lineage (osteo/chondro/adipo) differentiation potential, while the remainder displayed a bi-lineage (osteo/chondro) or uni-lineage potential (osteo).”