Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of t-cell function in advanced cancer patients.

By J. Schmielau, O. Finn. Cancer Research, 2001

941 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Arginase I Production in the Tumor Microenvironment by Mature Myeloid Cells Inhibits T-Cell Receptor Expression and Antigen-Specific T-Cell Responses (2004, background): “5 42 (41) (23) (36) (40) (32) OVA 20713 217 23842 20517 24562 (1050) (47.”
Polarization of Tumor-Associated Neutrophil (TAN) Phenotype by TGF-β: “N1” versus “N2” TAN (2009, background): “, 2003), and suppress the antitumor immune response (Schmielau and Finn, 2001).”
Arginase: an emerging key player in the mammalian immune system (2009, background): “Alternatively, activated PMN are known to aberrantly co-purify within the PBMC fraction of patients with tumours or inflammation (Schmielau and Finn, 2001), so that de novo arginase activity in the PBMC population under conditions of inflammation might actually be confined to the neutrophil subset (”
Antigen-Specific Inhibition of CD8+ T Cell Response by Immature Myeloid Cells in Cancer Is Mediated by Reactive Oxygen Species1 (2004, background): “Granulocyte-derived H2O2 has been shown to be involved in the inhibition of IFN- production and the suppression of CD3 -chain expression by T cells in advanced cancer patients (18).”