Role of BRCA2 in control of the RAD51 recombination and DNA repair protein.

By A. Davies, J. Masson, Michael J. McIlwraith, A. Stasiak, Andrzej Stasiak, A. Venkitaraman, S. West. Molecules and Cells, 2001

743 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a7c16eea408a486c219c1116535f64d4c1536ad3

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Citations in the corpus

Regulation of homologous recombination in eukaryotes (2010, background): “Furthermore, BRCA2 and the RAD51 paralog, RAD51C, are also involved in nuclear transport of RAD51 after DNA damage (40, 61).”
Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination (2010, positive): “These repeats bind RAD51 and control RAD51 nucleoprotein filament formation in conjunction with the BRCA2 DNA-binding domain, whereas another RAD51-binding motif at the C terminus of BRCA2, unrelated to the BRC repeats, seems to stabilize the filamen”
DNA double-strand break repair: from mechanistic understanding to cancer treatment. (2007, background): “ing loading of Rad51 onto single-stranded DNA [119].”
BRCA2 is required for homology-directed repair of chromosomal breaks. (2001, background): “BRCA2 and Rad51 proteins in these cells (Spain et al., Since Western blotting indicated that Brca2 protein 1999; Davies et al., 2001).”
The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability (2006, background): “This was suggested to be a consequence of a direct interaction between a RAD51 monomer and a single BRC repeat, therefore preventing the RAD51 monomers from self-associating (Davies et al., 2001).”
Homologous recombination and human health: the roles of BRCA1, BRCA2 and associated proteins (2015, background): “An individual BRC peptide, when present in excess, disrupts RAD51 filament formation in vitro (Davies et al. 2001) and interferes with damage-induced RAD51 foci formation and HR in vivo (Chen et al. 1999; Xia et al. 2001; Stark et al. 2002; Saeki et al. 2006), presumably by mimicking the interface…”
Association of Rad51 polymorphism with DNA repair in BRCA1 mutation carriers and sporadic breast cancer risk (2011, positive): “Rad51 was chosen for investigation because of their interactions with BRCA1 during homologous recombinational (HR) DNA repair [26].”
Insights into DNA recombination from the structure of a RAD51–BRCA2 complex (2002, background): “Notably, and in apparent conflict with these data, the activity of RAD51 in nucleoprotein filament formation is suppressed by its interaction with peptides encoding BRC repeat”
Molecular views of recombination proteins and their control (2003, background): “To investigate the effects that are imposed by BRC interaction on RAD51 activity, the DNA-binding properties of RAD51 were analysed in the presence of synthetic peptides corresponding to the BRC repeat”
Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair (2008, background): “BRC3 is a short peptide derived from BRCA2 that can inhibit RAD51 function [32].”